Evidence map›Paper›PMID 19046371›Full record

ArticleThe European journal of neuroscience2008

Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition.

Fernando Gomez-Pinilla, Shoshanna Vaynman, Zhe Ying

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European journal of neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04185298 (Mobile Technology-Based Simultaneous Aerobic Exercise and Memory Training Intervention for Older Adults With Mild Cognitive Impairment), which is not on this map. Cited by 160 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
160citing papers in PubMed, 3 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04185298 naterminatednot on this mapstarted 2019, after this paper: background citation

Mobile Technology-Based Simultaneous Aerobic Exercise and Memory Training Intervention for Older Adults With Mild Cognitive Impairment

TypeinterventionalSponsorJennifer BramenRan2019 to 2023Enrolled12ConditionsAmnestic Mild Cognitive ImpairmentArmsmSIM intervention plus activity monitoring, Activity monitoring
3 · Its place in the literature

Who cites it

160 citing papers in PubMed, 3 syntheses or guidelines pooled it, 373 citations in OpenAlex.

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  10. The effects of sports activity on cognition in nine- and ten-year-old children.Journal of the International Neuropsychological Society : JINS · 2026
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100 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Fernando Gomez-PinillaDepartment of Physiological Science, UCLA Brain Injury Research Center, Los Angeles, CA, USA. fgomezpi@ucla.edu
Shoshanna Vaynman
Zhe Ying
University of California, Los Angeles · US

Funding

Restoration of Homeostasis After Brain TraumaR01NS050465 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOMEZ-PINILLA, FERNANDO · 2005 to 2019
$5.5M
NINDS NIH HHS NS50465NINDS NIH HHS R01 NS050465
6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) has been shown to mediate the effects of exercise on synaptic plasticity and cognitive function, in a process in which energy metabolism probably plays an important role. The purpose of the present study was to examine the influence of exercise on rat hippocampal expression of molecules involved in the regulation of energy management and cognitive function, and to determine the role of BDNF in these events. One week of voluntary exercise that enhanced learning and memory performance elevated the expression of molecular systems involved in the metabolism of energy [AMP-activated protein kinase (AMPK), ubiquitous mitochondrial creatine kinase (uMtCK) and uncoupling protein 2] and molecules that work at the interface of energy and synaptic plasticity [BDNF, insulin-like growth factor I (IGF-I) and ghrelin]. The levels of BDNF mRNA were associated with the mRNA levels of AMPK, uMtCK, IGF-I and ghrelin. Inhibiting the action of BDNF during exercise abolished an exercise-mediated enhancement in spatial learning and increased the expression of all of the molecular systems studied. BDNF blocking also disrupted the association between learning speed and levels of AMPK, uMtCK, ghrelin and IGF-I mRNAs. These findings suggest that the effects of exercise on synaptic plasticity and cognitive function involve elements of energy metabolism, and that BDNF seems to work at the interface between the two processes as a metabotrophin.

Indexed as

Physical Conditioning, AnimalAdenylate KinaseAnimalsBrain-Derived Neurotrophic FactorCognitionCreatine Kinase, Mitochondrial FormEnergy MetabolismExercise TherapyGhrelinHippocampusInsulin-Like Growth Factor IIon ChannelsLearningMaleMemoryMitochondrial ProteinsAdenylate KinaseBrain-Derived Neurotrophic FactorCreatine Kinase, Mitochondrial FormGhrelinInsulin-Like Growth Factor IIon ChannelsMitochondrial ProteinsRNA, MessengerUcp2 protein, ratUncoupling Protein 2

Identifiers

PMID19046371
PMCPMC2805663
OpenAlexW2163006694

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.