Evidence map›Paper›PMID 19045817›Full record

ReviewIET systems biology2008

Network integration and graph analysis in mammalian molecular systems biology.

A Ma'ayan

Abstract readReview
In one paragraph

Review in IET systems biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Study of biological networks using graph theory.Saudi journal of biological sciences · 2018
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Tools for protein-protein interaction network analysis in cancer research.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2012
    Review
  8. Systems biology of kidney diseases.Kidney international · 2012
    Review
  9. Computational approaches for translational clinical research in disease progression.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2011
    Review
  10. Article
  11. Article
  12. A quick guide to large-scale genomic data mining.PLoS computational biology · 2010
    Article
  13. Review
  14. Article
  15. Systems biology of stem cell fate and cellular reprogramming.Nature reviews. Molecular cell biology · 2009
    Review
  16. Article
  17. Toward stem cell systems biology: from molecules to networks and landscapes.Cold Spring Harbor symposia on quantitative biology · 2008
    Review
  18. Toward a complete in silico, multi-layered embryonic stem cell regulatory network.Wiley interdisciplinary reviews. Systems biology and medicine
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

A Ma'ayanMount Sinai School of Medicine, Department of Pharmacology and Systems Therapeutics, New York, NY 10029-6574, USA. avi.maayan@mssm.edu

Funding

System Biology Center in New YorkP50GM071558 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ZAPH, SUSANA NEVES · 2007 to 2017
$22.8M
NIGMS NIH HHS 1P50GM071558-01A27398NIGMS NIH HHS P50 GM071558
6 · The paper itself

Abstract

Abstraction of intracellular biomolecular interactions into networks is useful for data integration and graph analysis. Network analysis tools facilitate predictions of novel functions for proteins, prediction of functional interactions and identification of intracellular modules. These efforts are linked with drug and phenotype data to accelerate drug-target and biomarker discovery. This review highlights the currently available varieties of mammalian biomolecular networks, and surveys methods and tools to construct, compare, integrate, visualise and analyse such networks.

Indexed as

AlgorithmsDatabases, ProteinModels, BiologicalAnimalsComputer SimulationHumansMammalsProtein Interaction MappingProteomeSignal TransductionStructure-Activity RelationshipSystems BiologySystems IntegrationProteome

Identifiers

PMID19045817
PMCPMC2745214

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.