ArticleParasitology research2009
The Wolbachia endosymbiont of Brugia malayi has an active phosphoglycerate mutase: a candidate target for anti-filarial therapies.
Article in Parasitology research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- The Wolbachia Symbiont: Here, There and Everywhere.Results and problems in cell differentiation · 2020Article
- Article
- Molecular identification of Wolbachia and Sodalis glossinidius in the midgut of Glossina fuscipes quanzensis from the Democratic Republic of Congo.Parasite (Paris, France) · 2019Article
- Glucose and Glycogen Metabolism in Brugia malayi Is Associated with Wolbachia Symbiont Fitness.PloS one · 2016Article
- Wolbachia transcription elongation factor "Wol GreA" interacts with α2ββ'σ subunits of RNA polymerase through its dimeric C-terminal domain.PLoS neglected tropical diseases · 2014Article
- Presence of extensive Wolbachia symbiont insertions discovered in the genome of its host Glossina morsitans morsitans.PLoS neglected tropical diseases · 2014Article
- A field survey for Wolbchia and phage WO infections of Aedes albopictus in Guangzhou City, China.Parasitology research · 2014Article
- Current drug targets for helminthic diseases.Parasitology research · 2013Review
- Potential therapeutic drug target identification in Community Acquired-Methicillin Resistant Staphylococcus aureus (CA-MRSA) using computational analysis.Bioinformation · 2012Article
- New insights into the evolution of Wolbachia infections in filarial nematodes inferred from a large range of screened species.PloS one · 2011Article
- Article
- The Wolbachia endosymbiont as an anti-filarial nematode target.Symbiosis (Philadelphia, Pa.) · 2010Article
- Filarial and Wolbachia genomics.Parasite immunologyReview
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Phosphoglycerate mutases (PGM) interconvert 2- and 3-phosphoglycerate in the glycolytic and gluconeogenic pathways. A putative cofactor-independent phosphoglycerate mutase gene (iPGM) was identified in the genome sequence of the Wolbachia endosymbiont from the filarial nematode, Brugia malayi (wBm). Since iPGM has no sequence or structural similarity to the cofactor-dependent phosphoglycerate mutase (dPGM) found in mammals, it may represent an attractive Wolbachia drug target. In the present study, wBm-iPGM cloned and expressed in Escherichia coli was mostly insoluble and inactive. However, the protein was successfully produced in the yeast Kluyveromyces lactis and the purified recombinant wBm-iPGM showed typical PGM activity. Our results provide a foundation for further development of wBm-iPGM as a promising new drug target for novel anti-filarial therapies that selectively target the endosymbiont.
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