ArticlePloS one2008
Modulation of the NF-kappaB pathway by Bordetella pertussis filamentous hemagglutinin.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- C-terminal domain of the filamentous hemagglutinin FhaB is crucial for interaction ofbioRxiv : the preprint server for biology · 2026Article
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- Filamentous Hemagglutinin ofInternational journal of molecular sciences · 2022Article
- Pathogenicity and virulence ofVirulence · 2021Review
- Rumen epithelial transcriptome and microbiome profiles of rumen epithelium and contents of beef cattle with and without liver abscesses.Journal of animal science · 2020Article
- Screening and Genomic Characterization of Filamentous Hemagglutinin-Deficient Bordetella pertussis.Infection and immunity · 2018Article
- Rationale for Adjunctive Therapies for Pediatric Sepsis Induced Multiple Organ Failure.Pediatric clinics of North America · 2017Review
- The prodomain of the Bordetella two-partner secretion pathway protein FhaB remains intracellular yet affects the conformation of the mature C-terminal domain.Molecular microbiology · 2012Article
- Contribution of Bordetella filamentous hemagglutinin and adenylate cyclase toxin to suppression and evasion of interleukin-17-mediated inflammation.Infection and immunity · 2012Article
- Intruders below the radar: molecular pathogenesis of Bartonella spp.Clinical microbiology reviews · 2012Review
- Modulation of NF-κB signalling by microbial pathogens.Nature reviews. Microbiology · 2011Review
- Article
- Modulation of the host interferon response and ISGylation pathway by B. pertussis filamentous hemagglutinin.PloS one · 2011Article
- Intracellular trafficking of Bordetella pertussis in human macrophages.Infection and immunity · 2010Article
- Pathogenic Bacterial Proteins and their Anti-Inflammatory Effects in the Eukaryotic Host.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2009Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundFilamentous hemagglutinin (FHA) is a cell-associated and secreted adhesin produced by Bordetella pertussis with pro-apoptotic and pro-inflammatory activity in host cells. Given the importance of the NF-kappaB transcription factor family in these host cell responses, we examined the effect of FHA on NF-kappaB activation in macrophages and bronchial epithelial cells, both of which are relevant cell types during natural infection. METHODOLOGY/PRINCIPAL
findingsExposure to FHA of primary human monocytes and transformed U-937 macrophages, but not BEAS-2B epithelial cells, resulted in early activation of the NF-kappaB pathway, as manifested by the degradation of cytosolic IkappaB alpha, by NF-kappaB DNA binding, and by the subsequent secretion of NF-kappaB-regulated inflammatory cytokines. However, exposure of macrophages and human monocytes to FHA for two hours or more resulted in the accumulation of cytosolic IkappaB alpha, and the failure of TNF-alpha to activate NF-kappaB. Proteasome activity was attenuated following exposure of cells to FHA for 2 hours, as was the nuclear translocation of RelA in BEAS-2B cells.
conclusionsThese results reveal a complex temporal dynamic, and suggest that despite short term effects to the contrary, longer exposures of host cells to this secreted adhesin may block NF-kappaB activation, and perhaps lead to a compromised immune response to this bacterial pathogen.
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Registered trials
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