ArticleJournal of neuroscience methods2009
A novel method for precisely timed stimulation of mouse whiskers in a freely moving preparation: application for delivery of the conditioned stimulus in trace eyeblink conditioning.
Article in Journal of neuroscience methods, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- An Open-Source 3D-Printable Platform for Testing Head-Fixed Cognitive Flexibility in Rodents.eNeuro · 2025Article
- Impact of anesthesia exposure in early development on learning and sensory functions.Developmental psychobiology · 2020Review
- Development of an imaging system for in vivo real-time monitoring of neuronal activity in deep brain of free-moving rats.Histochemistry and cell biology · 2017Article
- Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice.Journal of visualized experiments : JoVE · 2016Article
- Synaptic tagging during memory allocation.Nature reviews. Neuroscience · 2014Review
- Training-dependent associative learning induced neocortical structural plasticity: a trace eyeblink conditioning analysis.PloS one · 2014Article
- Article
- Reevaluating hippocampus-dependent learning in FVB/N mice.Behavioral neuroscience · 2011Article
- Age-related deficits in a forebrain-dependent task, trace-eyeblink conditioning.Neurobiology of aging · 2011Article
- Anatomical pathways involved in generating and sensing rhythmic whisker movements.Frontiers in integrative neuroscience · 2011Article
- Rat psychomotor vigilance task with fast response times using a conditioned lick behavior.Behavioural brain research · 2011Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The somatosensory whisker pathway has been a useful system for increasing our understanding of experience-induced plasticity. However, precisely timed whisker activation in the awake freely moving mouse has been very difficult. This manuscript describes a method for construction of a whisker stimulator that can be attached to a freely moving mouse. The stimulator was used to activate the whiskers in a time-sensitive forebrain-dependent task, trace eyeblink conditioning. After repeatedly pairing whisker stimulation with delivery of a mild periorbital shock following a stimulus-free trace interval, trace-conditioned mice were able to learn the association. This study demonstrates the potential for using the whisker stimulator in time-sensitive behavioral tasks, such as trace eyeblink conditioning, thus enhancing our ability to examine experience-induced neuronal plasticity in the somatosensory whisker pathway in awake behaving rodents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.