Evidence map›Paper›PMID 19041864›Full record

ReviewExperimental cell research2009

ERBBs in the gastrointestinal tract: recent progress and new perspectives.

William H Fiske, David Threadgill, Robert J Coffey

Open access · greenAbstract readReview
In one paragraph

Review in Experimental cell research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis.Biochimica et biophysica acta. Molecular cell research · 2017
    Review
  4. Review
  5. Article
  6. ADAM Proteases and Gastrointestinal Function.Annual review of physiology · 2016
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. The EGFR family: not so prototypical receptor tyrosine kinases.Cold Spring Harbor perspectives in biology · 2014
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

William H FiskeDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
David Threadgill
Robert J Coffey
Vanderbilt University Medical Center · USUniversity of North Carolina at Chapel Hill · US

Funding

Understanding and Controlling p120 Dysfunction in CRCP50CA095103 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 2002 to 2017
$33.6M
TISSUE PROCUREMENT &ANALYSISP50CA106991 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TEPPER, JOEL E · 2004 to 2009
$12.1M
TRANSFORMING GROWTH FACTORS IN COLONIC NEOPLASIAR01CA046413 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 1988 to 2016
$8.8M
Prevention &Metastasis: Final Frontiers in Colon CancerU01CA084239 · NCI · VANDERBILT UNIVERSITY · PI COFFEY, ROBERT J. · 1999 to 2009
$8.0M
Modeling heterogeneity for safe cancer prevention and detectionU01CA105417 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THREADGILL, DAVID W. · 2004 to 2013
$6.7M
ERBB receptors in normal and cancerous colon biologyR01CA092479 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THREADGILL, DAVID W. · 2001 to 2012
$2.8M
Genetic control of colorectal cancer histopathologyR01CA079869 · NCI · VANDERBILT UNIVERSITY · PI THREADGILL, DAVID W. · 1999 to 2013
$2.7M
NCI NIH HHS P50 CA095103NCI NIH HHS P50 CA106991NCI NIH HHS P50CA106991NCI NIH HHS P50CA95103NCI NIH HHS R01 CA046413NCI NIH HHS R01 CA079869NCI NIH HHS R01 CA092479NCI NIH HHS R01CA092479NCI NIH HHS R01CA46413NCI NIH HHS U01 CA084239NCI NIH HHS U01CA084239NCI NIH HHS U01 CA105417NCI NIH HHS U01CA105417
6 · The paper itself

Abstract

The gastrointestinal epithelium does much more than provide a physical barrier between the intestinal lumen and our internal milieu. It is actively engaged in absorption and secretion of salt and water via ion transporters, exchangers and selective ion channels. It is also a continuously self-renewing epithelium that undergoes ordered growth and differentiation along its vertical axis. From this dual perspective, we will consider the actions of the ERBB family of ligands and receptors in the maintenance of gastrointestinal homeostasis and discuss instances when the actions of this family go awry such as in cancer and Ménétrier's disease.

Indexed as

ErbB ReceptorsGastrointestinal TractHomeostasisHumansOncogene Proteins v-erbBSignal TransductionTranscriptional ActivationErbB ReceptorsOncogene Proteins v-erbB

Identifiers

PMID19041864
PMCPMC2941795
OpenAlexW2021101047

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.