ArticleDevelopmental biology2009
Notochord-derived BMP antagonists inhibit endothelial cell generation and network formation.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Inducing Angiogenesis in the Nucleus Pulposus.Cells · 2023Article
- Avians as a Model System of Vascular Development.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Human notochordal cell transcriptome unveils potential regulators of cell function in the developing intervertebral disc.Scientific reports · 2018Article
- Fibronectin signals through integrin α5β1 to regulate cardiovascular development in a cell type-specific manner.Developmental biology · 2015Article
- Soluble factors from the notochordal-rich intervertebral disc inhibit endothelial cell invasion and vessel formation in the presence and absence of pro-inflammatory cytokines.Osteoarthritis and cartilage · 2015Article
- Avians as a model system of vascular development.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Diversity is in my veins: role of bone morphogenetic protein signaling during venous morphogenesis in zebrafish illustrates the heterogeneity within endothelial cells.Arteriosclerosis, thrombosis, and vascular biology · 2014Review
- Shape and position of the node and notochord along the bilateral plane of symmetry are regulated by cell-extracellular matrix interactions.Biology open · 2014Article
- Notochordal cell-derived therapeutic strategies for discogenic back pain.Global spine journal · 2013Review
- Vascular development in the zebrafish.Cold Spring Harbor perspectives in medicine · 2012Review
- Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels.Circulation research · 2012Article
- Enhancement of human adipose-derived stromal cell angiogenesis through knockdown of a BMP-2 inhibitor.Plastic and reconstructive surgery · 2012Article
- Nonintegrating knockdown and customized scaffold design enhances human adipose-derived stem cells in skeletal repair.Stem cells (Dayton, Ohio) · 2011Article
- Early arterial differentiation and patterning in the avian embryo model.Seminars in cell & developmental biology · 2011Review
- Bone Morphogenetic Protein functions as a context-dependent angiogenic cue in vertebrates.Seminars in cell & developmental biology · 2011Review
- Isolation and characterization of node/notochord-like cells from mouse embryonic stem cells.Stem cells and development · 2011Article
- Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein.Nature cell biology · 2011Article
- Promotion of avian endothelial cell differentiation by GATA transcription factors.Developmental biology · 2011Article
- Head and neck lymphatic tumors and bony abnormalities: a clinical and molecular review.Lymphatic research and biology · 2011Review
- An anteroposterior wave of vascular inhibitor downregulation signals aortae fusion along the embryonic midline axis.Development (Cambridge, England) · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Embryonic blood vessel formation is initially mediated through the sequential differentiation, migration, and assembly of endothelial cells (ECs). While many molecular signals that promote vascular development have been identified, little is known about suppressors of this process. In higher vertebrates, including birds and mammals, the vascular network forms throughout the embryonic disk with the exception of a region along the midline. We have previously shown that the notochord is responsible for the generation and maintenance of the avascular midline and that BMP antagonists expressed by this embryonic tissue, including Noggin and Chordin, can mimic this inhibitory role. Here we report that the notochord suppresses the generation of ECs from the mesoderm both in vivo and in vitro. We also report that the notochord diminishes the ability of mature ECs to organize into a primitive plexus. Furthermore, Noggin mimics notochord-based inhibition by preventing mesodermal EC generation and mature EC network formation. These findings suggest that the mesoderm surrounding the midline is competent to give rise to ECs and to form blood vessels, but that notochord derived-BMP antagonists suppress EC differentiation and maturation processes leading to inhibition of midline vessel formation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.