Evidence map›Paper›PMID 19041825›Full record

ReviewBest practice & research. Clinical endocrinology & metabolism2008

Molecular pathology of thyroid cancer: diagnostic and clinical implications.

James A Fagin, Nicholas Mitsiades

Abstract readReview
In one paragraph

Review in Best practice & research. Clinical endocrinology & metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. BRAF V600E and Novel Somatic Mutations in Thyroid Cancer of Libyan Patients.Asian Pacific journal of cancer prevention : APJCP · 2022
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
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  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

James A FaginDepartment of Medicine and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA. faginj@mskcc.org
Nicholas Mitsiades

Funding

MOLECULAR PATHOPHYSIOLOGY OF THYROID CELL GROWTHR01CA050706 · NCI · UNIVERSITY OF CINCINNATI · PI FAGIN, JAMES A · 1995 to 2023
$7.5M
ONCOGENIC EVENTS IN THYROID NEOPLASIAR01CA072597 · NCI · UNIVERSITY OF CINCINNATI · PI FAGIN, JAMES A · 1997 to 2020
$6.7M
MOLECULAR PATHOPHYSIOLOGY OF THYROID CELL GROWTHR29CA050706 · NCI · CEDARS-SINAI MEDICAL CENTER · PI FAGIN, JAMES A · 1989 to 1993
–
NCI NIH HHS CA50706NCI NIH HHS CA72597NCI NIH HHS R01 CA050706NCI NIH HHS R01 CA072597
6 · The paper itself

Abstract

There is now a reasonably good understanding of the key oncogenic events involved in the initiation and progression of thyroid cancer. Many of these are characteristic of certain tumor types, and their presence conveys diagnostic and prognostic information. It is not yet clear how this information will be applied to clinical practice. Based on preclinical evidence, mutations of genes encoding certain kinases may also predict response to specific tyrosine kinase inhibitors, although this has not yet been explored systematically in clinical trials.

Indexed as

Carcinoma, Papillary, FollicularHumansPhosphatidylinositol 3-KinasesProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-retPTEN Phosphohydrolaseras ProteinsThyroid NeoplasmsBRAF protein, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-retPTEN Phosphohydrolaseras ProteinsRET protein, human

Identifiers

PMID19041825
PMCPMC2615540

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.