ArticleBiochimica et biophysica acta2009
Transcriptional regulation of mouse L-selectin.
Article in Biochimica et biophysica acta, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Krüppel-like Factor 2 (KLF2) in Immune Cell Migration.Vaccines · 2021Review
- L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling.Frontiers in immunology · 2019Review
- Article
- Real-time tracking of cell cycle progression during CD8+ effector and memory T-cell differentiation.Nature communications · 2015Article
- Transiently reduced PI3K/Akt activity drives the development of regulatory function in antigen-stimulated Naïve T-cells.PloS one · 2013Article
- FOXO1 Up-Regulates Human L-selectin Expression Through Binding to a Consensus FOXO1 Motif.Gene regulation and systems biology · 2012Article
- Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1).Nature immunology · 2011Article
- Foxo: in command of T lymphocyte homeostasis and tolerance.Trends in immunology · 2011Review
- Krüppel-like factor 2 regulates trafficking and homeostasis of gammadelta T cells.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Memory CD8+ T cell differentiation.Annals of the New York Academy of Sciences · 2010Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
L-selectin mediates the initial tethering and rolling of lymphocytes in high endothelial venules. To study the transcriptional regulation of mouse L-selectin, we cloned 4.5 kb 5'-flanking sequences of the mouse sell. Luciferase analysis of serial 5'-deletion mutants showed that the first 285 bp was sufficient to drive high promoter activity in EL4 cells, but not in Sell-negative HeLa cells, suggesting that this fragment harbors the minimal mouse sell promoter and contains cis-elements for lymphocyte-specific expression. Site-directed mutagenesis and chromatin immunoprecipitation showed that Mzf1, Klf2, Sp1, Ets1, and Irf1 bind to and activate the mouse sell promoter. Over expression of these transcription factors in EL4 cells increased expression of sell mRNA. Silencing the expression of Sp1 by siRNA significantly decreased sell promoter activity in EL4 cells. We conclude that sell transcription is regulated by Mzf1, Klf2, Sp1, Ets1, and Irf1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.