ArticleMolecular microbiology2009
Vacuole inheritance regulates cell size and branching frequency of Candida albicans hyphae.
Article in Molecular microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Snooping helices: The elastic path finding algorithm of growing hyphae.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Microfluidic live-cell imaging of Aspergillus fumigatus and Candida albicans hyphal growth treated with AmBisome and Caspofungin.Journal of microscopy · 2026Article
- Aloin remodels the cell wall of Candida albicans to reduce its hyphal virulence against oral candidiasis.Applied microbiology and biotechnology · 2025Article
- FgVAC1 is an Essential Gene Required for Golgi-to-Vacuole Transport and Fungal Development in Fusarium graminearum.Journal of microbiology (Seoul, Korea) · 2024Article
- The vacuolar fusion regulated by HOPS complex promotes hyphal initiation and penetration in Candida albicans.Nature communications · 2024Article
- Carvacrol-Induced Vacuole Dysfunction and Morphological Consequences inMicroorganisms · 2023Article
- A C. albicans TRAPP Complex-Associated Gene Contributes to Cell Wall Integrity, Hyphal and Biofilm Formation, and Tissue Invasion.Microbiology spectrum · 2023Article
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- A novel phosphoinositide kinase Fab1 regulates biosynthesis of pathogenic aflatoxin inVirulence · 2021Article
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- The Role of Secretory Pathways inJournal of fungi (Basel, Switzerland) · 2020Review
- Simple Carbohydrate Derivatives Diminish the Formation of Biofilm of the Pathogenic YeastAntibiotics (Basel, Switzerland) · 2019Article
- The casein kinase MoYck1 regulates development, autophagy, and virulence in the rice blast fungus.Virulence · 2019Article
- Multi-omics Analyses Reveal Synergistic Carbohydrate Metabolism in Streptococcus mutans-Candida albicans Mixed-Species Biofilms.Infection and immunity · 2019Article
- A HOPS Protein, MoVps41, Is Crucially Important for Vacuolar Morphogenesis, Vegetative Growth, Reproduction and Virulence inFrontiers in plant science · 2017Article
- Calcineurin and Calcium Channel CchA Coordinate the Salt Stress Response by Regulating Cytoplasmic Ca2+ Homeostasis in Aspergillus nidulans.Applied and environmental microbiology · 2016Article
- High frame-rate resolution of cell division during Candida albicans filamentation.Fungal genetics and biology : FG & B · 2016Article
- Plasma membrane organization promotes virulence of the human fungal pathogen Candida albicans.Journal of microbiology (Seoul, Korea) · 2016Review
- Distinct roles of Candida albicans-specific genes in host-pathogen interactions.Eukaryotic cell · 2014Article
- β-catenin in plants and animals: common players but different pathways.Frontiers in plant science · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hyphal growth of Candida albicans is characterized by asymmetric cell divisions in which the subapical mother cell inherits most of the vacuolar space and becomes cell cycle arrested in G1, while the apical daughter cell acquires most of the cell cytoplasm and progresses through G1 into the next mitotic cell cycle. Consequently, branch formation in hyphal compartments is delayed until sufficient cytoplasm is synthesized to execute the G1 'START' function. To test the hypothesis that this mode of vacuole inheritance determines cell cycle progression and therefore the branching of hyphae, eight tetracycline-regulated conditional mutants were constructed that were affected at different stages of the vacuole inheritance pathway. Under repressing conditions, vac7, vac8 and fab1 mutants generated mycelial compartments with more symmetrically distributed vacuoles and increased branching frequencies. Repression of VAC1, VAM2 and VAM3 resulted in sparsely branched hyphae, with large vacuoles and enlarged hyphal compartments. Therefore, during hyphal growth of C. albicans the cell cycle, growth and branch formation can be uncoupled, resulting in the investment of cytoplasm to support hyphal extension at the expense of hyphal branching.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.