ArticleHuman genetics2009
A genetic association study in the Gambia using tagging polymorphisms in the major histocompatibility complex class III region implicates a HLA-B associated transcript 2 polymorphism in severe malaria susceptibility.
Article in Human genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Micronutrients intake and genetic variants associated with premature ovarian insufficiency; MASHAD cohort study.BMC women's health · 2024Article
- Genetic variants in BAT2 are associated with immune responsiveness to influenza vaccination.Frontiers in genetics · 2023Article
- Common genetic variants in PRRC2A are associated with both neuromyelitis optica spectrum disorder and multiple sclerosis in Han Chinese population.Journal of neurology · 2021Article
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- DDX39B (BAT1), TNF and IL6 gene polymorphisms and association with clinical outcomes of patients with Plasmodium vivax malaria.Malaria journal · 2014Article
- Association of cytokine and Toll-like receptor gene polymorphisms with severe malaria in three regions of Cameroon.PloS one · 2013Article
- Human candidate polymorphisms in sympatric ethnic groups differing in malaria susceptibility in Mali.PloS one · 2013Article
- The host genetic diversity in malaria infection.Journal of tropical medicine · 2012Article
- Investigation of host candidate malaria-associated risk/protective SNPs in a Brazilian Amazonian population.PloS one · 2012Article
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- Host candidate gene polymorphisms and clearance of drug-resistant Plasmodium falciparum parasites.Malaria journal · 2011Article
- A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults.Malaria journal · 2010Article
- Extended LTA, TNF, LST1 and HLA gene haplotypes and their association with rubella vaccine-induced immunity.PloS one · 2010Article
- Human lymphocyte antigen B-associated transcript 2, 3, and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm.Journal of clinical laboratory analysis · 2010Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
The tumour necrosis factor (TNF) gene and other genes flanking it in the major histocompatibility complex (MHC) class III region are potentially important mediators of both immunity and pathogenesis of malaria. We investigated the association of severe malaria with 11 haplotype tagging-polymorphisms for 11 MHC class III candidate genes, including TNF, lymphotoxin alpha (LTA), allograft inflammatory factor 1 (AIF1), and HLA-B associated transcript 2 (BAT2). An analysis of 2,162 case-controls demonstrated the first evidence of association between a BAT2 polymorphism (rs1046089) and severe malaria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.