ArticleParasitology research2009
Assessment of Balamuthia mandrillaris-specific serum antibody concentrations by flow cytometry.
Article in Parasitology research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Various brain-eating amoebae: the protozoa, the pathogenesis, and the disease.Frontiers of medicine · 2021Review
- The Epidemiology and Clinical Features of Balamuthia mandrillaris Disease in the United States, 1974-2016.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Assessment of blood-brain barrier penetration of miltefosine used to treat a fatal case of granulomatous amebic encephalitis possibly caused by an unusual Balamuthia mandrillaris strain.Parasitology research · 2015Article
- Amino Acid Uptake and Metabolism of Legionella pneumophila Hosted by Acanthamoeba castellanii.The Journal of biological chemistry · 2014Article
- Serologic survey for exposure following fatal Balamuthia mandrillaris infection.Parasitology research · 2014Article
- Balamuthia mandrillaris amoebic encephalitis: an emerging parasitic infection.Current infectious disease reports · 2012Article
- Identification of antigenic targets for immunodetection of Balamuthia mandrillaris infection.Clinical and vaccine immunology : CVI · 2011Article
- Diagnosis of infections caused by pathogenic free-living amoebae.Interdisciplinary perspectives on infectious diseases · 2009Article
- Review
- Management of granulomatous amebic encephalitis: Laboratory diagnosis and treatment.Tropical parasitologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A flow cytometry (fluorescence-activated cell sorter)-based assay was adapted to detect and quantify antibodies to Balamuthia mandrillaris, a causative agent of fatal amoebic encephalitis (BAE), and to Acanthamoeba species. With sera from BAE patients for positive and a group of inconspicuous volunteers for negative reference, most of the 237 sera from random blood donors, patients with atypical encephalitis, atypical pneumonitis, visceral amoebiasis and toxoplasmosis and from subjects working with primates and other mammals were rated negative, 19% elevated and of these 2% high. In comparison, 23 of 25 West Africans living in rural areas revealed elevated, of these 15 high, and one very high B. mandrillaris-binding antibody titers, the latter well in the range of BAE patients. To date, none of the tested individuals have developed symptoms indicative of BAE. Criss-cross analysis with rabbit hyper immune sera against B. mandrillaris, Acanthamoeba comandoni (group 1), Acanthamoeba castellanii (group 2) and Acanthamoeba lenticulata (group 3) confirmed that cross-reactivity between B. mandrillaris and Acanthamoeba sp. is negligible while accentuating antigenic differences between the three morphological groups of Acanthamoeba.
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