ArticleJournal of the American College of Cardiology2008
Myogenic endothelial cells purified from human skeletal muscle improve cardiac function after transplantation into infarcted myocardium.
Article in Journal of the American College of Cardiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 80 citations in OpenAlex.
- On vasa vasorum: A history of advances in understanding the vessels of vessels.Science advances · 2022Review
- CD133+ cells derived from skeletal muscles of Duchenne muscular dystrophy patients have a compromised myogenic and muscle regenerative capability.Stem cell research · 2018Article
- Stem/Progenitor Cells and Their Therapeutic Application in Cardiovascular Disease.Frontiers in cell and developmental biology · 2018Review
- Regenerative Translation of Human Blood-Vessel-Derived MSC Precursors.Stem cells international · 2015Review
- Isolation of blood-vessel-derived multipotent precursors from human skeletal muscle.Journal of visualized experiments : JoVE · 2014Article
- Concise review: skeletal muscle stem cells and cardiac lineage: potential for heart repair.Stem cells translational medicine · 2014Review
- Molecular and cell-based therapies for muscle degenerations: a road under construction.Frontiers in physiology · 2014Review
- The role of antioxidation and immunomodulation in postnatal multipotent stem cell-mediated cardiac repair.International journal of molecular sciences · 2013Review
- Human myogenic endothelial cells exhibit chondrogenic and osteogenic potentials at the clonal level.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2013Article
- Stem cell therapy for pediatric dilated cardiomyopathy.Current cardiology reports · 2013Review
- Muscle-derived stem cell sheets support pump function and prevent cardiac arrhythmias in a model of chronic myocardial infarction.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- Human pericytes for ischemic heart repair.Stem cells (Dayton, Ohio) · 2013Article
- Cellular kinetics of perivascular MSC precursors.Stem cells international · 2013Review
- Intrinsic ability of adult stem cell in skeletal muscle: an effective and replenishable resource to the establishment of pluripotent stem cells.Stem cells international · 2013Article
- Separate or combined treatments with daily sildenafil, molsidomine, or muscle-derived stem cells prevent erectile dysfunction in a rat model of cavernosal nerve damage.The journal of sexual medicine · 2012Article
- The vascular stem cell niche.Journal of cardiovascular translational research · 2012Review
- Microfluidic single-cell analysis shows that porcine induced pluripotent stem cell-derived endothelial cells improve myocardial function by paracrine activation.Circulation research · 2012Article
- Effects of sildenafil and/or muscle derived stem cells on myocardial infarction.Journal of translational medicine · 2012Article
- Induced bone marrow mesenchymal stem cells improve cardiac performance of infarcted rat hearts.Molecular biology reports · 2012Article
- Human skeletal muscle cells with a slow adhesion rate after isolation and an enhanced stress resistance improve function of ischemic hearts.Molecular therapy : the journal of the American Society of Gene Therapy · 2012Article
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10 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThe aim of this study was to evaluate the therapeutic potential of human skeletal muscle-derived myoendothelial cells for myocardial infarct repair.
backgroundWe have recently identified and purified a novel population of myoendothelial cells from human skeletal muscle. These cells coexpress myogenic and endothelial cell markers and produce robust muscle regeneration when injected into cardiotoxin-injured skeletal muscle.
methodsMyoendothelial cells were isolated from biopsies of human skeletal muscle using a fluorescence-activated cell sorter along with populations of regular myoblasts and endothelial cells. Acute myocardial infarction was induced in male immune-deficient mice, and cells were directly injected into the ischemic area. Cardiac function was assessed by echocardiography, and donor cell engraftment, angiogenesis, scar tissue, endogenous cardiomyocyte proliferation, and apoptosis were all evaluated by immunohistochemistry.
resultsA greater improvement in left ventricular function was observed after intramyocardial injection of myoendothelial cells when compared with that seen in hearts injected with myoblast or endothelial cells. Transplanted myoendothelial cells generated robust engraftments within the infarcted myocardium, and also stimulated angiogenesis, attenuation of scar tissue, and proliferation and survival of endogenous cardiomyocytes more effectively than transplanted myoblasts or endothelial cells.
conclusionsOur findings suggest that myoendothelial cells represent a novel cell population from human skeletal muscle that may hold promise for cardiac repair.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.