ArticleFree radical biology & medicine2009
Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas.
Article in Free radical biology & medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- Techniques to study chimerism at the tissue level in humanized mice.Veterinary pathology · 2026Article
- Oxidative phosphorylation and breast cancer progression: insights into PGC-1α's role in mitochondrial function.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Bioinformatics Analysis of ceRNA Network Related to Polycystic Ovarian Syndrome.Computational and mathematical methods in medicine · 2021Article
- Mitochondrial complex II and V activity is enhanced in pediatric acute myeloid leukemia.American journal of blood research · 2021Article
- The NOR1/OSCP1 proteins in cancer: from epigenetic silencing to functional characterization of a novel tumor suppressor.Journal of Cancer · 2017Review
- Regulation of mitochondrial genome replication by hypoxia: The role of DNA oxidation in D-loop region.Free radical biology & medicine · 2016Article
- Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory complex-I activity via Bcl-2 family proteins.Oncotarget · 2014Article
- Calcium co-regulates oxidative metabolism and ATP synthase-dependent respiration in pancreatic beta cells.The Journal of biological chemistry · 2014Article
- Metabolic symbiosis in cancer: refocusing the Warburg lens.Molecular carcinogenesis · 2013Review
- Part III. Molecular changes induced by high nitric oxide adaptation in human breast cancer cell line BT-20 (BT-20-HNO): a switch from aerobic to anaerobic metabolism.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Mitochondrial alteration in malignantly transformed human small airway epithelial cells induced by α-particles.International journal of cancer · 2013Article
- Combination therapy targeting cancer metabolism.Medical hypotheses · 2011Review
- Article
- p53 and regulation of bioactive sphingolipids.Advances in enzyme regulation · 2011Review
- Quantitative proteome analysis of pluripotent cells by iTRAQ mass tagging reveals post-transcriptional regulation of proteins required for ES cell self-renewal.Molecular & cellular proteomics : MCP · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Lymphomas adapt to their environment by undergoing a complex series of biochemical changes that are currently not well understood. To better define these changes, we examined the gene expression and gene ontology profiles of thymic lymphomas from a commonly used model of carcinogenesis, the p53(-/-) mouse. These tumors show a highly significant upregulation of mitochondrial biogenesis, mitochondrial protein translation, mtDNA copy number, reactive oxygen species, antioxidant defenses, proton transport, ATP synthesis, hypoxia response, and glycolysis, indicating a fundamental change in the bioenergetic profile of the transformed T cell. Our results suggest that T cell tumorigenesis involves a simultaneous upregulation of mitochondrial biogenesis, mitochondrial respiration, and glycolytic activity. These processes would allow cells to adapt to the stressful tumor environment by facilitating energy production and thereby promote tumor growth. Understanding these adaptations is likely to result in improved therapeutic strategies for this tumor type.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.