ReviewNeuron2008
New dogs in the dogma: Lrp4 and Tid1 in neuromuscular synapse formation.
Review in Neuron, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Analysis of theCells · 2024Article
- Mitochondrial co-chaperone protein Tid1 is required for energy homeostasis during skeletal myogenesis.Stem cell research & therapy · 2016Article
- Structural mechanisms of the agrin-LRP4-MuSK signaling pathway in neuromuscular junction differentiation.Cellular and molecular life sciences : CMLS · 2013Review
- Agrin-signaling is necessary for the integration of newly generated neurons in the adult olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Molecular mechanism of active zone organization at vertebrate neuromuscular junctions.Molecular neurobiology · 2012Review
- [Neuromuscular signal transmission in adulthood. Current facets of acquired and hereditary disorders].Der Nervenarzt · 2011Article
- A single immunoglobulin-domain protein required for clustering acetylcholine receptors in C. elegans.The EMBO journal · 2011Article
- Secreted factors as synaptic organizers.The European journal of neuroscience · 2010Review
- WNTs tune up the neuromuscular junction.Nature reviews. Neuroscience · 2009Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two recent papers reported identification of a long-sought agrin coreceptor, Lrp4 (Kim et al. in Cell and Zhang et al. in Neuron). In this issue of Neuron, Linnoila et al. report the identification of a new player in the agrin-MuSK pathway, Tid1, which directly interacts with MuSK and is responsible for transducing signals from MuSK activation to AChR clustering, culminating in cross-linking to the subsynaptic cytoskeleton. These papers substantially reshape the agrin-MuSK-ACh hypothesis of neuromuscular synaptogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.