ArticleBMC evolutionary biology2008
Divergent evolution and molecular adaptation in the Drosophila odorant-binding protein family: inferences from sequence variation at the OS-E and OS-F genes.
Article in BMC evolutionary biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 29 citations in OpenAlex.
- Adaptive Evolution of Odorant-Binding and Chemosensory Protein Gene Families in GenusBiomolecules · 2026Article
- Antennal Transcriptome Screening and Identification of Chemosensory Proteins in the Double-Spine European Spruce Bark Beetle,International journal of molecular sciences · 2024Article
- A supergene in seaweed flies modulates male traits and female perception.Proceedings. Biological sciences · 2023Article
- The genome of the stable fly, Stomoxys calcitrans, reveals potential mechanisms underlying reproduction, host interactions, and novel targets for pest control.BMC biology · 2021Article
- Comparative Genomics Provide Insights Into Function and Evolution of Odorant Binding Proteins inFrontiers in physiology · 2021Article
- Odorant-binding proteins expression patterns in recently diverged species of Anastrepha fruit flies.Scientific reports · 2017Article
- Head Transcriptomes of Two Closely Related Species of Fruit Flies of the Anastrepha fraterculus Group Reveals Divergent Genes in Species with Extensive Gene Flow.G3 (Bethesda, Md.) · 2016Article
- Molecular evolution of Odorant-binding proteins gene family in two closely related Anastrepha fruit flies.BMC evolutionary biology · 2016Article
- Weak Polygenic Selection Drives the Rapid Adaptation of the Chemosensory System: Lessons from the Upstream Regions of the Major Gene Families.Genome biology and evolution · 2016Article
- Identification of pheromone components and their binding affinity to the odorant binding protein CcapOBP83a-2 of the Mediterranean fruit fly, Ceratitis capitata.Insect biochemistry and molecular biology · 2014Article
- Global Transcriptional Analysis of Olfactory Genes in the Head of Pine Shoot Beetle, Tomicus yunnanensis.Comparative and functional genomics · 2012Article
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- Making scents of behavioural genetics: lessons from Drosophila.Genetics research · 2010Review
- Natural variation, functional pleiotropy and transcriptional contexts of odorant binding protein genes in Drosophila melanogaster.Genetics · 2010Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Drosophila Odorant-Binding Protein (Obp) genes constitute a multigene family with moderate gene number variation across species. The OS-E and OS-F genes are the two phylogenetically closest members of this family in the D. melanogaster genome. In this species, these genes are arranged in the same genomic cluster and likely arose by tandem gene duplication, the major mechanism proposed for the origin of new members in this olfactory-system family.
resultsWe have analyzed the genomic cluster encompassing OS-E and OS-F genes (Obp83 genomic region) to determine the role of the functional divergence and molecular adaptation on the Obp family size evolution. We compared nucleotide and amino acid variation across 18 Drosophila and 4 mosquito species applying a phylogenetic-based maximum likelihood approach complemented with information of the OBP three-dimensional structure and function. We show that, in spite the OS-E and OS-F genes are currently subject to similar and strong selective constraints, they likely underwent divergent evolution. Positive selection was likely involved in the functional diversification of new copies in the early stages after the gene duplication event; moreover, it might have shaped nucleotide variation of the OS-E gene concomitantly with the loss of functionally related members. Besides, molecular adaptation likely affecting the functional OBP conformational changes was supported by the analysis of the evolution of physicochemical properties of the OS-E protein and the location of the putative positive selected amino acids on the OBP three-dimensional structure.
conclusionOur results support that positive selection was likely involved in the functional differentiation of new copies of the OBP multigene family in the early stages after their birth by gene duplication; likewise, it might shape variation of some members of the family concomitantly with the loss of functionally related genes. Thus, the stochastic gene gain/loss process coupled with the impact of natural selection would influence the observed OBP family size.
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