ArticleClinical and experimental immunology2008
Impaired dendritic cell maturation and cytokine production in patients with chronic mucocutanous candidiasis with or without APECED.
Article in Clinical and experimental immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines.The Journal of experimental medicine · 2010Trial
- Preliminary Evidence for Autoimmune Regulator Occupancy at Promoter Regions of Known Autoantigens in Human Peripheral Lymphocytes Obtained by Chromatin Immunoprecipitation Assay.International journal of molecular sciences · 2026Article
- Article
- Tissue-specific autoimmunity controlled by Aire in thymic and peripheral tolerance mechanisms.International immunology · 2020Article
- IL-22 neutralizing autoantibodies impair fungal clearance in murine oropharyngeal candidiasis model.European journal of immunology · 2018Article
- Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.Cell host & microbe · 2017Article
- Altered Immune Activation and IL-23 Signaling in Response toFrontiers in immunology · 2017Article
- Learning from other diseases: protection and pathology in chronic fungal infections.Seminars in immunopathology · 2016Review
- Article
- Antifungal Th Immunity: Growing up in Family.Frontiers in immunology · 2014Review
- Human APECED; a Sick Thymus Syndrome?Frontiers in immunology · 2013Review
- Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis.Current opinion in allergy and clinical immunology · 2012Review
- Expanding the clinical and genetic spectrum of human CD40L deficiency: the occurrence of paracoccidioidomycosis and other unusual infections in Brazilian patients.Journal of clinical immunology · 2012Article
- Immunity to fungal infections.Nature reviews. Immunology · 2011Review
- Pathogenesis and treatment of oral candidosis.Journal of oral microbiology · 2011Article
- The role of the IL-12 cytokine family in directing T-cell responses in oral candidosis.Clinical & developmental immunology · 2011Review
- Epithelial cells and innate antifungal defense.Journal of dental research · 2010Review
- Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I.The Journal of experimental medicine · 2010Article
- Pattern recognition receptor expression is not impaired in patients with chronic mucocutanous candidiasis with or without autoimmune polyendocrinopathy candidiasis ectodermal dystrophy.Clinical and experimental immunology · 2009Article
- Rethinking T cell immunity in oropharyngeal candidiasis.The Journal of experimental medicine · 2009Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with chronic mucocutaneous candidiasis (CMC) suffer persistent infections with the yeast Candida. CMC includes patients with autoimmune regulator (AIRE) gene mutations who have autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED), and patients without known mutations. CMC patients have dysregulated cytokine production, and dendritic cells (DCs), as central orchestrators, may underlie pathogenic disease mechanisms. In 29 patients with CMC (13 with APECED) and controls, we generated monocyte-derived DCs, stimulated them with Candida albicans, Toll-like receptor-2/6 ligand and lipopolysaccharide to assess cytokine production [interleukin (IL)-12p70, IL-23, interferon (IFN)-gamma, IL-2, tumour necrosis factor (TNF)-alpha, IL-6, transforming growth factor-beta, IL-10, IL-5, IL-13] and cell-surface maturation marker expression (CD83, CD86, human leucocyte antigen D-related). In both APECED and non-APECED CMC patients, we demonstrate impairment of DC function as evidenced by altered cytokine expression profiles and DC maturation/activation: (1) both groups over-produce IL-2, IFN-gamma, TNF-alpha and IL-13 and demonstrate impaired DC maturation. (2) Only non-APECED patients showed markedly decreased Candida-stimulated production of IL-23 and markedly increased production of IL-6, suggesting impairment of the IL-6/IL-23/T helper type 17 axis. (3) In contrast, only APECED patients showed DC hyperactivation, which may underlie altered T cell responsiveness, autoimmunity and impaired response to Candida. We demonstrate different pathogenic mechanisms on the same immune response pathway underlying increased susceptibility to Candida infection in these patients.
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