Evidence map›Paper›PMID 19037733›Full record

ArticleCancer causes & control : CCC2009

Diet and expression of estrogen alpha and progesterone receptors in the normal mammary gland.

Pagona Lagiou, Evangelia Samoli, Areti Lagiou, Christina Georgila, Pantelina Zourna, Anastasia Barbouni, George Gkiokas, Dorothy Vassilarou, Annivas Tsikkinis, Constantinos Sfikas and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Pagona LagiouDepartment of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 M. Asias Street, Goudi 115 27, Greece.
Evangelia Samoli
Areti Lagiou
Christina Georgila
Pantelina Zourna
Anastasia Barbouni
George Gkiokas
Dorothy Vassilarou
Annivas Tsikkinis
Constantinos Sfikas
Constantine E Sekeris
Chung-Cheng Hsieh
Hans-Olov Adami
Dimitrios Trichopoulos
National and Kapodistrian University of Athens · GRHarvard University · USNational Hellenic Research Foundation · GRNational School of Public Health · GRProlepsis Institute · GRUMass Memorial Health Care · US

Funding

DIET AND ESTROGEN RECEPTORS IN NORMAL MAMMARY TISSUER03CA089823 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI TRICHOPOULOS, DIMITRIOS V · 2001 to 2002
$162k
NCI NIH HHS CA89823NCI NIH HHS R03 CA089823
6 · The paper itself

Abstract

objectiveIt has been recently reported that expression of estrogen alpha (ER-alpha) and progesterone (PR) receptors in the normal mammary gland is inversely associated with breast cancer risk among postmenopausal women. We investigated whether dietary intakes are associated with the expression of ER-alpha and PR receptors in the apparently normal, as opposed to pathological, mammary tissue.

methodsIn a study in Greece, we examined associations of dietary intakes with ER-alpha and PR expression in the adjacent-to-pathological apparently normal mammary tissue of 562 women with either breast cancer (267 women) or BBD (299 women). Diet was assessed through an extensive food frequency questionnaire and results were analyzed using multiple logistic regression.

resultsMonounsaturated (p = 0.03) and, to a lesser extent, polyunsaturated lipids (p = 0.08) were positively associated with ER-alpha expression. Cereals and starchy roots were inversely associated with ER-alpha (p = 0.01), whereas milk and dairy products were inversely associated with PR expression (p = 0.02). Ethanol intake was non-significantly inversely associated with ER-alpha expression (p = 0.07).

conclusionsOur findings suggest that the weak associations of diet with breast cancer risk could be explained, to some extent, by effects of diet on receptor expression in the normal mammary gland.

Indexed as

DietAdultAgedBreast NeoplasmsDiet SurveysEstrogen Receptor alphaFemaleHumansLogistic ModelsMammary Glands, HumanMiddle AgedReceptors, ProgesteroneEstrogen Receptor alphaReceptors, Progesterone

Identifiers

PMID19037733
PMCPMC3096822
OpenAlexW2062197623

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.