ArticleHistochemistry and cell biology2009
New morphological aspects of blood islands formation in the embryonic mouse hearts.
Article in Histochemistry and cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Desmoglein 2 regulates cardiogenesis by restricting hematopoiesis in the developing murine heart.Scientific reports · 2021Article
- Insights into blood cell formation from hemogenic endothelium in lesser-known anatomic sites.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Extravascular endothelial and hematopoietic islands form through multiple pathways in midgestation mouse embryos.Developmental biology · 2016Article
- The Histochemistry and Cell Biology omnium-gatherum: the year 2015 in review.Histochemistry and cell biology · 2016Review
- Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos.eLife · 2015Article
- Vasculogenic and hematopoietic cellular progenitors are scattered within the prenatal mouse heart.Histochemistry and cell biology · 2015Article
- Extending the knowledge in histochemistry and cell biology.Histochemistry and cell biology · 2010Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vasculogenesis in embryonic hearts proceeds by formation of aggregates consisting of erythroblasts and endothelial cells. These aggregates are called blood-islands or blood-island-like structures. We aimed to characterize blood islands in mouse embryonic hearts at stages spanning from 11 dpc through 13 dpc, i.e. prior to the establishment of the coronary circulation. Our observations suggested that there are two types of blood islands. One formed by migrating nucleated erythroblasts, which associated with migrating endothelial cell and the second by in situ emergence of two kinds of cells belonging to separate populations: one resembling an erythroblast progenitor and the second resembling an endothelial-cell progenitor. The subepicardial blood islands contain nucleated erythroblasts, undifferentiated mesenchymal cells, platelets, and early lymphocytes. The subepicardial blood islands resemble vesicles with protruding prongs directed toward the myocardium. Ahead of the prongs, angiogenic sprouting and degradation of fibronectin is observed. Vesicles gradually change their shape from spherical to tubular at 13 dpc and grow and extend along the interventricular sulcuses forming vascular tubes. We presume that the vascular tubes located within the interventricular sulcuses are precursors of coronary veins. Our data seems to indicate that embryonic heart vasculogenesis is accompanied by hematopoiesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.