ArticleMolecular imaging and biology
Detection of visual activation in the rat brain using 2-deoxy-2-[(18)F]fluoro-D: -glucose and statistical parametric mapping (SPM).
Article in Molecular imaging and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
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- Cortico-Amygdala-Striatal Activation by Modafinil/Flecainide Combination.The international journal of neuropsychopharmacology · 2018Article
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- Sex Differences in Regional Brain Glucose Metabolism Following Opioid Withdrawal and Replacement.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Imaging Sex Differences in Regional Brain Metabolism during Acute Opioid Withdrawal.Journal of alcoholism and drug dependence · 2017Article
- Response to deep brain stimulation in the lateral hypothalamic area in a rat model of obesity: in vivo assessment of brain glucose metabolism.Molecular imaging and biology · 2014Article
- Micro-positron emission tomography imaging of rat brain metabolism during expression of contextual conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study was designed to assess changes in brain glucose metabolism in rats after visual stimulation. MATERIALS AND
methodsWe sought to determine whether visual activation in the rat brain could be detected using a small-animal positron emission tomography (PET) scanner and 2-deoxy-2-[(18)F]fluoro-D: -glucose (FDG). Eleven rats were divided into two groups: (a) five animals exposed to ambient light and (b) six animals stimulated by stroboscopic light (10 Hz) with one eye covered. Rats were injected with FDG and, after 45 min of visual stimulation, were sacrificed and scanned for 90 min in a dedicated PET tomograph. Images were reconstructed by a three-dimensional ordered subset expectation maximization algorithm (1.8 mm full width at half maximum). A region-of-interest (ROI) analysis was performed on 14 brain structures drawn on coronal sections. Statistical parametric mapping (SPM) adapted for small animals was also carried out. Additionally, the brains of three rats were sliced into 20-microm sections for autoradiography.
resultsAnalysis of ROI data revealed significant differences between groups in the right superior colliculus, right thalamus, and brainstem (p < or = 0.05). SPM detected the same areas as the ROI approach. Autoradiographs confirmed the existence of hyperactivation in the left superior colliculus and auditory cortex.
conclusionsTo our knowledge, this is the first report that uses FDG-PET and SPM analysis to show changes in rat brain glucose metabolism after a visual stimulus.
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