ArticleHeart and vessels2008
High immunoglobulin A seropositivity for combined Chlamydia pneumoniae, Helicobacter pylori infection, and high-sensitivity C-reactive protein in coronary artery disease patients in India can serve as atherosclerotic marker.
Article in Heart and vessels, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- A Comprehensive Survey of the Relationship betweenArchives of Iranian medicine · 2022Pooled it
- Cytomegalovirus infection and coronary heart disease risk: a meta-analysis.Molecular biology reports · 2012Pooled it
- A link between platelet to lymphocyte ratio and Helicobacter pylori infection.Journal of clinical laboratory analysis · 2018Trial
- Association of neutrophil to lymphocyte ratio with presence and severity of gastritis due to Helicobacter pylori infection.Journal of clinical laboratory analysis · 2014Trial
- Cardiovascular and Neurological Diseases and Association with Helicobacter Pylori Infection-An Overview.Diagnostics (Basel, Switzerland) · 2024Review
- Associated Bacterial Coinfections in COVID-19-Positive Patients.Medicina (Kaunas, Lithuania) · 2023Article
- Worldwide Prevalence and Risk Factors ofChildren (Basel, Switzerland) · 2022Review
- Old and New Aspects ofChildren (Basel, Switzerland) · 2022Review
- Innate immunity - the hallmark ofWorld journal of clinical cases · 2021Article
- ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities - Role of gut microbiota dysbiosis.Ageing research reviews · 2020Review
- The usefulness of inflammatory biomarkers in diagnosing child and adolescent's gastritis: STROBE compliant article.Medicine · 2019Article
- Potential Anti-Inflammatory Treatment of Ischemic Heart Disease.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2018Article
- Effect ofJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016Article
- Helicobacter pylori: Does it add to risk of coronary artery disease.World journal of cardiology · 2015Review
- Pathogen burden, cytomegalovirus infection and inflammatory markers in the risk of premature coronary artery disease in individuals of Indian origin.Experimental and clinical cardiology · 2012Article
- Association of serum levels of arachidonic acid and eicosapentaenoic acid with prevalence of major adverse cardiac events after acute myocardial infarction.Heart and vessels · 2011Article
- Association of plasma circulatory markers, Chlamydia pneumoniae, and high sensitive C-reactive protein in coronary artery disease patients of India.Mediators of inflammation · 2009Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerosis is increasingly recognized as a chronic inflammatory disease. A variety of infectious agents (Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus [CMV]) and inflammatory marker such as high-sensitivity C-reactive protein (hs-CRP) have been found to be associated with atherosclerosis and its consequences. There is a need to know about the type and burden of infection in coronary artery disease (CAD) patients and the level of hs-CRP in India as there is growing evidence that a variety of pathogens are participating in the development and/or acceleration of at least pre-existing atherosclerosis. In addition, there is a need to find the association between these pathogens and conventional risk factors among CAD patients in India, to possibly identify a prognostic marker. In this study 192 patients with incident or prevalent CAD attending the Cardiology Outpatient Department of Safdarjung Hospital, New Delhi, India, were enrolled. In addition, 192 age-and sex-matched controls were also included. Cases and controls differ significantly in seropositivity to C. pneumoniae immunoglobulin IgA (154 vs 76) and IgG (71 vs 48) (P < 0.001, P < 0.015), H. pylori IgA (98 vs 57) and IgG (77 vs 43) (P < 0.001, P < 0.001), CMV IgG (62 vs 38) (P = 0.01) and with hs-CRP (114 vs 60) (P < 0.001), respectively. The level of hs-CRP was higher in CAD patients with IgA seropositivity of C. pneumoniae and H. pylori (5.18 and.65 mg/l) than the IgG of these bacteria (3.73 and 3.36 mg/l), respectively. These findings support an association between specific infectious agents, namely, C. pneumoniae, H. pylori, CMV, and hs-CRP in CAD patients. Association of hs-CRP with IgA specific for C. pneumoniae and H. pylori suggests the role of chronic infection in the development of CAD and may be used as a marker to target the population.
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