ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2009
Role of variation in the serotonin transporter protein gene (SLC6A4) in trait disturbances in the ventral anterior cingulate in bipolar disorder.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Facial emotion recognition deficits in bipolar disorder: A systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2026Pooled it
- The effect of the serotonin transporter polymorphism (5-HTTLPR) on amygdala function: a meta-analysis.Molecular psychiatry · 2013Pooled it
- Glycogen synthase kinase-3ß supports serotonin transporter function and trafficking in a phosphorylation-dependent manner.Journal of neurochemistry · 2021Article
- Reliability of neural activation and connectivity during implicit face emotion processing in youth.Developmental cognitive neuroscience · 2018Article
- Shared facial emotion processing functional network findings in medication-naïve major depressive disorder and healthy individuals: detection by sICA.BMC psychiatry · 2018Article
- Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder.The American journal of psychiatry · 2017Article
- Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Review
- Parametric modulation of neural activity during face emotion processing in unaffected youth at familial risk for bipolar disorder.Bipolar disorders · 2014Article
- Postnatal day 2 to 11 constitutes a 5-HT-sensitive period impacting adult mPFC function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Fronto-limbic-striatal dysfunction in pediatric and adult patients with bipolar disorder: impact of face emotion and attentional demands.Psychological medicine · 2014Article
- Serotonin transporter genotype modulates cognitive reappraisal of negative emotions: a functional magnetic resonance imaging study.Social cognitive and affective neuroscience · 2013Article
- Elevated amygdala responses to emotional faces in youths with chronic irritability or bipolar disorder.NeuroImage. Clinical · 2013Article
- Functional neuroanatomy of bipolar disorder: structure, function, and connectivity in an amygdala-anterior paralimbic neural system.Bipolar disorders · 2012Review
- Trait and state corticostriatal dysfunction in bipolar disorder during emotional face processing.Bipolar disorders · 2012Article
- Prefrontal cortical response to emotional faces in individuals with major depressive disorder in remission.Psychiatry research · 2012Article
- Euthymia, depression, and mania: what do we know about the switch?Biological psychiatry · 2012Article
- Neural activation during facial emotion processing in unmedicated bipolar depression, euthymia, and mania.Biological psychiatry · 2012Article
- Stress reactivity and corticolimbic response to emotional faces in adolescents.Journal of the American Academy of Child and Adolescent Psychiatry · 2012Article
- Article
- Serotonin transporter genotype modulates subgenual response to fearful faces using an incidental task.Journal of cognitive neuroscience · 2011Article
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Authors and funding
10 authors at 2 institutions in 1 country.
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Abstract
Bipolar disorder (BD) is associated with abnormalities of the ventral anterior cingulate cortex (vACC) and its connection sites, including the amygdala, which are key components of a corticolimbic neural system that subserves emotional regulation. Decreased functional connectivity from the vACC to the amygdala in healthy individuals is associated with the short 's' allele--as opposed to the long 'l' allele--of a well-known serotonin transporter promoter polymorphism (5-HTTLPR, locus SLC6A4), as are features of BD. This study tests the hypothesis that the s allele influences dysfunction in the vACC-amygdala neural system in BD. A total of 30 euthymic individuals with BD (20 s carriers, 10 ll) and 48 healthy comparison (HC) participants (34 s, 14 ll) participated in an event-related functional magnetic resonance imaging scan while processing fearful, happy, or neutral faces. During fear and happy face processing, vACC activation was significantly lower in the BD compared to the HC group, and in s carriers compared to ll individuals within both the HC and BD groups, such that BD s carriers exhibited the greatest magnitude of vACC dysfunction. No significant differences were detected in amygdala activation. The findings suggest that the 5-HTTLPR s allele may contribute to a trait-related, genetically derived, neurobiological subgroup within BD characterized by prominent vACC dysfunction. Future treatment may be optimized for this BD subgroup by targeting the serotonergic system and the vACC.
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