ArticleMolecular biology of the cell2009
Knockdown of p180 eliminates the terminal differentiation of a secretory cell line.
Article in Molecular biology of the cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- Expression of RRBP1 in epithelial ovarian cancer and its clinical significance.Bioscience reports · 2019Trial
- ER biogenesis without stress: how the ribosome receptor, p180, defines a developmental program beyond the UPR.Frontiers in cell and developmental biology · 2025Article
- Stabilization of RRBP1 mRNA via an mCellular and molecular life sciences : CMLS · 2024Article
- Quantitative Mass Spectrometry Characterizes Client Spectra of Components for Targeting of Membrane Proteins to and Their Insertion into the Membrane of the Human ER.International journal of molecular sciences · 2023Review
- ER ribosomal-binding protein 1 regulates blood pressure and potassium homeostasis by modulating intracellular renin trafficking.Journal of biomedical science · 2023Article
- RRBP1 depletion of bone metastatic cancer cells contributes to enhanced expression of the osteoblastic phenotype.Frontiers in oncology · 2022Article
- Comparative transcriptome provides insights into the selection adaptation between wild and farmed foxes.Ecology and evolution · 2021Article
- Hypomethylated RRBP1 Potentiates Tumor Malignancy and Chemoresistance in Upper Tract Urothelial Carcinoma.International journal of molecular sciences · 2021Article
- RRBP1 is highly expressed in prostate cancer and correlates with prognosis.Cancer management and research · 2019Article
- Expression and significance of RRBP1 in esophageal carcinoma.Cancer management and research · 2018Article
- Article
- Myogenic Progenitor Cells Control Extracellular Matrix Production by Fibroblasts during Skeletal Muscle Hypertrophy.Cell stem cell · 2017Article
- Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly.Viruses · 2016Review
- ER sheet persistence is coupled to myosin 1c-regulated dynamic actin filament arrays.Molecular biology of the cell · 2014Article
- Endoplasmic reticulum stress induces different molecular structural alterations in human dilated and ischemic cardiomyopathy.PloS one · 2014Article
- Endoplasmic reticulum structure and interconnections with other organelles.Cold Spring Harbor perspectives in biology · 2013Review
- Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration.International review of cell and molecular biology · 2013Review
- Progressive sheet-to-tubule transformation is a general mechanism for endoplasmic reticulum partitioning in dividing mammalian cells.Molecular biology of the cell · 2012Article
- Overexpression of ribosome binding protein 1 (RRBP1) in breast cancer.Clinical proteomics · 2012Article
- p180 promotes the ribosome-independent localization of a subset of mRNA to the endoplasmic reticulum.PLoS biology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We have previously reported that the expression in yeast of an integral membrane protein (p180) of the endoplasmic reticulum (ER), isolated for its ability to mediate ribosome binding, is capable of inducing new membrane biogenesis and an increase in secretory capacity. To demonstrate that p180 is necessary and sufficient for terminal differentiation and acquisition of a secretory phenotype in mammalian cells, we studied the differentiation of a secretory cell line where p180 levels had been significantly reduced using RNAi technology and by transiently expressing p180 in nonsecretory cells. A human monocytic (THP-1) cell line, that can acquire macrophage-like properties, failed to proliferate rough ER when p180 levels were lowered. The Golgi compartment and the secretion of apolipoprotein E (Apo E) were dramatically affected in cells expressing reduced p180 levels. On the other hand, expression of p180 in a human embryonic kidney nonsecretory cell line (HEK293) showed a significant increase in proliferation of rough ER membranes and Golgi complexes. The results obtained from knockdown and overexpression experiments demonstrate that p180 is both necessary and sufficient to induce a secretory phenotype in mammalian cells. These findings support a central role for p180 in the terminal differentiation of secretory cells and tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.