ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Modeling a negative response bias in the human amygdala by noradrenergic-glucocorticoid interactions.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pharmacological manipulations of judgement bias: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2020Pooled it
- The effects of suppressing the biological stress systems on social threat-assessment following acute stress.Psychopharmacology · 2020Trial
- Individual differences in amygdala reactivity following nicotinic receptor stimulation in abstinent smokers.NeuroImage · 2013Trial
- Serotonergic and noradrenergic modulation of emotion processing by single dose antidepressants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Trial
- Article
- Healthy women with severe early life trauma show altered neural facilitation of emotion inhibition under acute stress.Psychological medicine · 2020Article
- Acute stress selectively impairs learning to act.Scientific reports · 2016Article
- Cortisol effects on fear memory reconsolidation in women.Psychopharmacology · 2016Article
- GANEing traction: The broad applicability of NE hotspots to diverse cognitive and arousal phenomena.The Behavioral and brain sciences · 2016Article
- Acute Stress Dysregulates the LPP ERP Response to Emotional Pictures and Impairs Sustained Attention: Time-Sensitive Effects.Brain sciences · 2015Article
- ADRA2B genotype differentially modulates stress-induced neural activity in the amygdala and hippocampus during emotional memory retrieval.Psychopharmacology · 2015Article
- Children's cortisol and salivary alpha-amylase interact to predict attention bias to threatening stimuli.Physiology & behavior · 2015Article
- Acute psychosocial stress and emotion regulation skills modulate empathic reactions to pain in others.Frontiers in psychology · 2014Article
- Norepinephrine transporter heterozygous knockout mice exhibit altered transport and behavior.Genes, brain, and behavior · 2013Article
- Norepinephrine transporter variant A457P knock-in mice display key features of human postural orthostatic tachycardia syndrome.Disease models & mechanisms · 2013Article
- The roles of noradrenergic and glucocorticoid activation in the development of intrusive memories.PloS one · 2013Article
- Acute stress induces selective alterations in cost/benefit decision-making.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Mineralocorticoid receptor Iso/Val (rs5522) genotype moderates the association between previous childhood emotional neglect and amygdala reactivity.The American journal of psychiatry · 2012Article
- Contextual control over expression of fear is affected by cortisol.Frontiers in behavioral neuroscience · 2012Article
- Time-dependent effects of cortisol on selective attention and emotional interference: a functional MRI study.Frontiers in integrative neuroscience · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An emerging theme in the neuroscience of emotion is the question of how acute stress shapes, and distorts, social-emotional behavior. The prevailing neurocircuitry models of social-emotional behavior emphasize the central role of the amygdala. Acute stress leads to increased central levels of norepinephrine (NE) and cortisol (CORT), and evidence suggests that these endogenous neuromodulators synergistically influence amygdala responses to social-emotional stimuli. We therefore hypothesized that amygdala responses to emotional facial expressions would be susceptible to pharmacologically induced increases in central NE and CORT levels. To specifically test this hypothesis, we measured amygdala activation to emotional faces using functional magnetic resonance imaging in 62 healthy subjects under four pharmacological conditions: (1) single oral dose of placebo, (2) 4 mg of the selective NE-reuptake inhibitor reboxetine (RBX), (3) 30 mg of hydrocortisone, or (4) both drugs in combination. We found that a decrease in amygdala activation to positive facial emotion was coupled with an increase in amygdala activation to negative facial emotion in the RBX-CORT combined challenge condition. In conclusion, a pharmacologically induced elevation of central NE and CORT levels in healthy subjects created a negative response bias in the amygdala that did not exist at baseline. Our results implicate a causative role of NE-CORT interactions in the emergence of a negative bias of cognitive and emotional functions which is germane in stress-related affective spectrum disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.