ArticleEndocrinology2009
Role of c-Myb during prolactin-induced signal transducer and activator of transcription 5a signaling in breast cancer cells.
Article in Endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- PIM Kinase Inhibitors as Novel Promising Therapeutic Scaffolds in Cancer Therapy.Current topics in medicinal chemistry · 2024Review
- Breast Cancer and Prolactin - New Mechanisms and Models.Endocrinology · 2022Review
- Alpha7 Nicotinic Acetylcholine Receptor Antagonists Prevent MeningiticBiomedicines · 2022Article
- Serine residues 726 and 780 have nonredundant roles regulating STAT5a activity in luminal breast cancer.Scientific reports · 2021Article
- Inhibition of the Activity of Cyclophilin A Impedes Prolactin Receptor-Mediated Signaling, Mammary Tumorigenesis, and Metastases.iScience · 2020Article
- c-Myb knockdown increases the neomycin-induced damage to hair-cell-like HEI-OC1 cells in vitro.Scientific reports · 2017Article
- MiR-15a suppresses hepatocarcinoma cell migration and invasion by directly targetingAmerican journal of translational research · 2017Article
- The transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cells.BMC cancer · 2014Article
- β-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivo.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Analysis and prediction of pathways in HeLa cells by integrating biological levels of organization with systems-biology approaches.PloS one · 2013Article
- The prolactin receptor transactivation domain is associated with steroid hormone receptor expression and malignant progression of breast cancer.The American journal of pathology · 2013Article
- Nemo-like kinase associated with proliferation and apoptosis by c-Myb degradation in breast cancer.PloS one · 2013Article
- Article
- Negative cross talk between NFAT1 and Stat5 signaling in breast cancer.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Signal transducer and activator of transcription 5 as a key signaling pathway in normal mammary gland developmental biology and breast cancer.Breast cancer research : BCR · 2011Review
- HMGN2 inducibly binds a novel transactivation domain in nuclear PRLr to coordinate Stat5a-mediated transcription.Molecular endocrinology (Baltimore, Md.) · 2011Article
- The early growth response gene Egr2 (Alias Krox20) is a novel transcriptional target of transforming growth factor-β that is up-regulated in systemic sclerosis and mediates profibrotic responses.The American journal of pathology · 2011Article
- Transcription factor c-Myb promotes the invasion of hepatocellular carcinoma cells via increasing osteopontin expression.Journal of experimental & clinical cancer research : CR · 2010Article
- The chicken miR-150 targets the avian orthologue of the functional zebrafish MYB 3'UTR target site.BMC molecular biology · 2010Article
- Cyclophilin B as a co-regulator of prolactin-induced gene expression and function in breast cancer cells.Journal of molecular endocrinology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Implicated in the pathogenesis of breast cancer, prolactin (PRL) mediates its function in part through the prolactin receptor (PRLr)-associated Janus kinase 2 (Jak2)/signal transducer and activator of transcription 5 (Stat5) signaling complex. To delineate the mechanisms of Stat5a regulation in breast cancer, transcription factor-transcription factor (TF-TF) array analysis was employed to identify associated transcriptional regulators. These analyses revealed a PRL-inducible association of Stat5a with the transcription factor and protooncogene c-Myb. Confirmatory co-immunoprecipitation studies using lysates from both T47D and MCF7 breast cancer cells revealed a PRL-inducible association between these transcription factors. Ectopic expression of c-Myb enhanced the PRL-induced expression from both composite and synthetic Stat5a-responsive luciferase reporters. Chromatin immunoprecipitation assays also revealed a PRL-inducible association between c-Myb and endogenous Stat5a-responsive CISH promoter, which was associated with an enhanced expression of CISH gene product at the RNA and protein levels. Small interfering RNA-mediated c-Myb knockdown impaired the PRL-induced mRNA expression of five Stat5-responsive genes. DNA binding-defective mutants of c-Myb, incapable of activating expression from a c-Myb-responsive reporter, maintained their ability to enhance a Stat5a-responsive reporter. At a cellular level, ectopic expression of c-Myb resulted in an increase in T47D proliferation. Taken together, these results indicate that c-Myb potentiates Stat5a-driven gene expression, possibly functioning as a Stat5a coactivator, in human breast cancer.
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