ArticleNucleic acids research2009
rasiRNA pathway controls antisense expression of Drosophila telomeric retrotransposons in the nucleus.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 58 citations in OpenAlex.
- RNA-binding protein Ars2 mediates transcriptional silencing of telomeric repeats and transposable elements in the Drosophila germline.Nucleic acids research · 2025Article
- Review
- Telomeric retrotransposons show propensity to form G-quadruplexes in various eukaryotic species.Mobile DNA · 2023Article
- The microRNA and the perspectives of miR-302.Heliyon · 2019Review
- Transcriptional quiescence in primordial germ cells.Critical reviews in biochemistry and molecular biology · 2018Review
- Article
- Drosophila: Retrotransposons Making up Telomeres.Viruses · 2017Review
- Transposable elements inMobile genetic elements · 2017Review
- Comparative transcriptomic analysis of human and Drosophila extracellular vesicles.Scientific reports · 2016Article
- ORC interacts with THSC/TREX-2 and its subunits promote Nxf1 association with mRNP and mRNA export in Drosophila.Nucleic acids research · 2016Article
- The piRNA Pathway Guards the Germline Genome Against Transposable Elements.Advances in experimental medicine and biology · 2016Review
- Telomeric repeat silencing in germ cells is essential for early development in Drosophila.Nucleic acids research · 2015Article
- Changes of Osvaldo expression patterns in germline of male hybrids between the species Drosophila buzzatii and Drosophila koepferae.Molecular genetics and genomics : MGG · 2015Article
- Article
- Euchromatic transposon insertions trigger production of novel Pi- and endo-siRNAs at the target sites in the drosophila germline.PLoS genetics · 2014Article
- Epigenetic control of mobile DNA as an interface between experience and genome change.Frontiers in genetics · 2014Review
- Untangling the web: the diverse functions of the PIWI/piRNA pathway.Molecular reproduction and development · 2013Review
- The maize b1 paramutation control region causes epigenetic silencing in Drosophila melanogaster.Molecular genetics and genomics : MGG · 2012Article
- Small RNA in the nucleus: the RNA-chromatin ping-pong.Current opinion in genetics & development · 2012Review
- The chromosomal proteins JIL-1 and Z4/Putzig regulate the telomeric chromatin in Drosophila melanogaster.PLoS genetics · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomeres in Drosophila are maintained by the specialized telomeric retrotransposons HeT-A, TART and TAHRE. Sense transcripts of telomeric retroelements were shown to be the targets of a specialized RNA-interference mechanism, a repeat-associated short interfering (rasi)RNA-mediated system. Antisense rasiRNAs play a key role in this mechanism, highlighting the importance of antisense expression in retrotransposon silencing. Previously, bidirectional transcription was reported for the telomeric element TART. Here, we show that HeT-A is also bidirectionally transcribed, and HeT-A antisense transcription in ovaries is regulated by a promoter localized within its 3' untranslated region. A remarkable feature of noncoding HeT-A antisense transcripts is the presence of multiple introns. We demonstrate that sense and antisense HeT-A-specific rasiRNAs are present in the same tissue, indicating that transcripts of both directions may be considered as natural targets of the rasiRNA pathway. We found that the expression of antisense transcripts of telomeric elements is regulated by the RNA silencing machinery, suggesting rasiRNA-mediated interplay between sense and antisense transcripts in the cell. Finally, this regulation occurs in the nucleus since disruption of the rasiRNA pathway leads to an accumulation of TART and HeT-A transcripts in germ cell nuclei.
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