ArticleNucleic acids research2009
Function and ribosomal localization of aIF6, a translational regulator shared by archaea and eukarya.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Investigation of the global translational response to oxidative stress in the model archaeonmSphere · 2025Article
- Evolutionary and functional relationships in the ribosome biogenesis SBDS and EFL1 protein families.Molecular genetics and genomics : MGG · 2021Article
- Tracing Eukaryotic Ribosome Biogenesis Factors Into the Archaeal Domain Sheds Light on the Evolution of Functional Complexity.Frontiers in microbiology · 2021Article
- The Archaeal Elongation Factor EF-2 Induces the Release of aIF6 From 50S Ribosomal Subunit.Frontiers in microbiology · 2021Article
- Indications for a moonlighting function of translation factor aIF5A in the crenarchaeum Sulfolobus solfataricus.RNA biology · 2019Article
- Leaderless mRNAs in the Spotlight: Ancient but Not Outdated!Microbiology spectrum · 2018Review
- Ribosome recycling is coordinated by processive events in two asymmetric ATP sites of ABCE1.Life science alliance · 2018Article
- Evolution of the archaeal and mammalian information processing systems: towards an archaeal model for human disease.Cellular and molecular life sciences : CMLS · 2017Review
- Article
- Protective Effects of Scutellarin on Human Cardiac Microvascular Endothelial Cells against Hypoxia-Reoxygenation Injury and Its Possible Target-Related Proteins.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Cryo-EM structure of the archaeal 50S ribosomal subunit in complex with initiation factor 6 and implications for ribosome evolution.Journal of molecular biology · 2012Article
- RsfA (YbeB) proteins are conserved ribosomal silencing factors.PLoS genetics · 2012Article
- An HflX-type GTPase from Sulfolobus solfataricus binds to the 50S ribosomal subunit in all nucleotide-bound states.Journal of bacteriology · 2011Article
- Translation initiation: variations in the mechanism can be anticipated.Cellular and molecular life sciences : CMLS · 2011Review
- The biological roles of ITGB4BP and its potential effect on fibrosis.International journal of burns and trauma · 2011Article
- Mechanism of eIF6-mediated inhibition of ribosomal subunit joining.The Journal of biological chemistry · 2010Article
- Analysis of ribosome biogenesis factor-modules in yeast cells depleted from pre-ribosomes.Nucleic acids research · 2010Article
- Maturation of eukaryotic ribosomes: acquisition of functionality.Trends in biochemical sciences · 2010Review
- Eukaryotic initiation factor 6 mediates a continuum between 60S ribosome biogenesis and translation.EMBO reports · 2009Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The translation factor IF6 is shared by the Archaea and the Eukarya, but is not found in Bacteria. The properties of eukaryal IF6 (eIF6) have been extensively studied, but remain somewhat elusive. eIF6 behaves as a ribosome-anti-association factor and is involved in miRNA-mediated gene silencing; however, it also seems to participate in ribosome synthesis and export. Here we have determined the function and ribosomal localization of the archaeal (Sulfolobus solfataricus) IF6 homologue (aIF6). We find that aIF6 binds specifically to the 50S ribosomal subunits, hindering the formation of 70S ribosomes and strongly inhibiting translation. aIF6 is uniformly expressed along the cell cycle, but it is upregulated following both cold- and heat shock. The aIF6 ribosomal binding site lies in the middle of the 30-S interacting surface of the 50S subunit, including a number of critical RNA and protein determinants involved in subunit association. The data suggest that the IF6 protein evolved in the archaeal-eukaryal lineage to modulate translational efficiency under unfavourable environmental conditions, perhaps acquiring additional functions during eukaryotic evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.