ArticleUltrasonics2009
Application of the dual-frequency ultrasonometer for osteoporosis detection.
Article in Ultrasonics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 40 citations in OpenAlex.
- Study of Ultrasonic Guided Wave Propagation in Bone Composite Structures for Revealing Osteoporosis Diagnostic Indicators.Materials (Basel, Switzerland) · 2023Article
- Axial Transmission: Techniques, Devices and Clinical Results.Advances in experimental medicine and biology · 2022Article
- Sensitivity of low-frequency axial transmission acoustics to axially and azimuthally varying cortical thickness: A phantom-based study.PloS one · 2019Article
- Towards assessing cortical bone porosity using low-frequency quantitative acoustics: A phantom-based study.PloS one · 2017Article
- Reliability of Phase Velocity Measurements of Flexural Acoustic Waves in the Human Tibia In-Vivo.PloS one · 2016Article
- Stimulation of osteoblast differentiation with guided ultrasound waves.Journal of therapeutic ultrasound · 2015Article
- Wave dispersion and attenuation on human femur tissue.Sensors (Basel, Switzerland) · 2014Article
- Multi-frequency axial transmission bone ultrasonometer.Ultrasonics · 2014Article
- Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer: clinical findings.Ultrasonics · 2014Article
- Ultrasound to assess bone quality.Current osteoporosis reports · 2014Article
- Axial transmission method for long bone fracture evaluation by ultrasonic guided waves: simulation, phantom and in vitro experiments.Ultrasound in medicine & biology · 2014Article
- Discrimination of fractures by low-frequency axial transmission ultrasound in postmenopausal females.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Article
- Cancellous bone analysis with modified least squares Prony's method and chirp filter: phantom experiments and simulation.The Journal of the Acoustical Society of America · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The paper presents results of a clinical validation study of Bone UltraSonic Scanner (BUSS), a novel dual-frequency axial transmission ultrasonometer, developed by Artann Laboratories. Assessment of bone conditions is based on evaluating relative changes of the axial profiles of ultrasonic characteristics in long bones and utilizes bulk and guided acoustic waves. The objective of this study was to determine the ability of BUSS to discriminate osteoporosis development stages. A total of 93 menopausal and post-menopausal women divided into five groups from normal to advanced osteoporosis according to their DXA hip t-score were enrolled in the study. The 2D waveform profiles at low (0.1 MHz) and high (1 MHz) frequencies were obtained by scanning 15 cm along the proximal tibia. A multi-parametric linear classifier based on a set of the parameters derived from 2D acoustic waveform profiles has been developed. The efficiency of this classifier in differentiating osteoporosis from a normal sample was assessed using a receiver operating characteristic (ROC) curve analysis. Based on the ROC analysis, BUSS demonstrated 76% sensitivity and 70% specificity to DXA-identified osteoporosis. The area under the ROC curve, which is a measure of how well a parameter can distinguish between the two diagnostic groups (diseased/normal) was 79.3%. The study confirmed BUSS's capability to discriminate between stages of bone atrophy and in particular to distinguish early changes induced by osteoporosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.