ArticleBMC microbiology2008
Antimicrobial peptides effectively kill a broad spectrum of Listeria monocytogenes and Staphylococcus aureus strains independently of origin, sub-type, or virulence factor expression.
Article in BMC microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Whole-Genome Sequencing of Multidrug-ResistantInternational journal of molecular sciences · 2026Article
- Changes in Amino Acid Metabolism ofMicroorganisms · 2022Article
- Inoculum effect of antimicrobial peptides.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A Real-Time Thermal Sensor System for Quantifying the Inhibitory Effect of Antimicrobial Peptides on Bacterial Adhesion and Biofilm Formation.Sensors (Basel, Switzerland) · 2021Article
- Reverse micelle-lipid nanocapsules: a novel strategy for drug delivery of the plectasin derivate AP138 antimicrobial peptide.International journal of nanomedicine · 2018Article
- Synergistic interactions between antimicrobial peptides derived from plectasin and lipid nanocapsules containing monolaurin as a cosurfactant againstInternational journal of nanomedicine · 2017Article
- Nematode Peptides with Host-Directed Anti-inflammatory Activity Rescue Caenorhabditis elegans from a Burkholderia pseudomallei Infection.Frontiers in microbiology · 2016Article
- Hyaluronic Acid-Based Nanogels Produced by Microfluidics-Facilitated Self-Assembly Improves the Safety Profile of the Cationic Host Defense Peptide Novicidin.Pharmaceutical research · 2015Article
- Human beta-defensin-3 producing cells in septic implant loosening.Journal of materials science. Materials in medicine · 2015Article
- Study on the Antimicrobial Properties of Citrate-Based Biodegradable Polymers.Frontiers in bioengineering and biotechnology · 2014Article
- Targeting listeria monocytogenes rpoA and rpoD genes using peptide nucleic acids.Nucleic acid therapeutics · 2013Article
- Sublethal triclosan exposure decreases susceptibility to gentamicin and other aminoglycosides in Listeria monocytogenes.Antimicrobial agents and chemotherapy · 2011Article
- Genome-wide dynamics of a bacterial response to antibiotics that target the cell envelope.BMC genomics · 2011Article
- Resistance and tolerance to tropodithietic acid, an antimicrobial in aquaculture, is hard to select.Antimicrobial agents and chemotherapy · 2011Article
- The heme sensing response regulator HssR in Staphylococcus aureus but not the homologous RR23 in Listeria monocytogenes modulates susceptibility to the antimicrobial peptide plectasin.BMC microbiology · 2010Article
- A novel approach to the antimicrobial activity of maggot debridement therapy.The Journal of antimicrobial chemotherapy · 2010Article
- The Opportunistic Pathogen Listeria monocytogenes: Pathogenicity and Interaction with the Mucosal Immune System.International journal of inflammation · 2010Article
- Kinetics of antimicrobial peptide activity measured on individual bacterial cells using high-speed atomic force microscopy.Nature nanotechnology · 2010Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHost defense peptides (HDPs), or antimicrobial peptides (AMPs), are important components of the innate immune system that bacterial pathogens must overcome to establish an infection and HDPs have been suggested as novel antimicrobial therapeutics in treatment of infectious diseases. Hence it is important to determine the natural variation in susceptibility to HDPs to ensure a successful use in clinical treatment regimes.
resultsStrains of two human bacterial pathogens, Listeria monocytogenes and Staphylococcus aureus, were selected to cover a wide range of origin, sub-type, and phenotypic behavior. Strains within each species were equally sensitive to HDPs and oxidative stress representing important components of the innate immune defense system. Four non-human peptides (protamine, plectasin, novicidin, and novispirin G10) were similar in activity profile (MIC value spectrum) to the human beta-defensin 3 (HBD-3). All strains were inhibited by concentrations of hydrogen peroxide between 0.1% - 1.0%. Sub-selections of both species differed in expression of several virulence-related factors and in their ability to survive in human whole blood and kill the nematode virulence model Caenorhabditis elegans. For L. monocytogenes, proliferation in whole blood was paralleled by high invasion in Caco-2 cells and fast killing of C. elegans, however, no such pattern in phenotypic behavior was observed for S. aureus and none of the phenotypic differences were correlated to sensitivity to HDPs.
conclusionStrains of L. monocytogenes and S. aureus were within each species equally sensitive to a range of HDPs despite variations in subtype, origin, and phenotypic behavior. Our results suggest that therapeutic use of HDPs will not be hampered by occurrence of naturally tolerant strains of the two species investigated in the present study.
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