ArticleJournal of the American Chemical Society2008
Membrane transporters for anions that use a relay mechanism.
Article in Journal of the American Chemical Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 71 citations in OpenAlex.
- Lipophilic mono-guanidinesRSC advances · 2026Article
- Medical and Nonmedical Applications of Synthetic Transmembrane Anion Transporters.Chemical reviews · 2025Review
- Article
- Highly Selective Artificial KJACS Au · 2024Article
- Molecular Machines For The Control Of Transmembrane Transport.Journal of the American Chemical Society · 2023Review
- Stimulus-Controlled Anion Binding and Transport by Synthetic Receptors.Chemical reviews · 2023Review
- Halogen bonding relay and mobile anion transporters with kinetically controlled chloride selectivity.Chemical science · 2023Article
- Cholesterol-stabilized membrane-active nanopores with anticancer activities.Nature communications · 2022Article
- A Photo-responsive Transmembrane Anion Transporter Relay.Journal of the American Chemical Society · 2022Article
- Editorial: Artificial Membrane Transporters.Frontiers in chemistry · 2022Article
- A Synthetic Phospholipid Derivative Mediates Ion Transport Across Lipid Bilayers.Frontiers in chemistry · 2021Article
- Inverse-phosphocholine lipids: a remix of a common phospholipid.Journal of the American Chemical Society · 2012Article
- Structure-activity relationships in tripodal transmembrane anion transporters: the effect of fluorination.Journal of the American Chemical Society · 2011Article
- Stopped-flow kinetic analysis of the interaction of cyclo[8]pyrrole with anions.Journal of the American Chemical Society · 2010Article
- Confocal imaging to quantify passive transport across biomimetic lipid membranes.Analytical chemistry · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A new type of synthetic membrane transporter is described and shown to operate in vesicles by a relay mechanism. The transporter structure is a phosphatidylcholine derivative with a urea group appended to the end of its sn-2 acyl chain. The urea can bind a chloride ion at the membrane surface via hydrogen bonds and then relay it through the bilayer interior to an acceptor molecule located in the opposite membrane leaflet. Three phosphatidylcholine derivatives were studied and transport rates increased with transporter affinity for chloride. The results of various controls studies are consistent with an anion countertransport process using a relay mechanism and a kinetically active aggregate of two or four transporter molecules. Transport is inhibited if the transporter resides in only one leaflet of the membrane, if the bilayer is too thick, and if the counteranion is sulfate dianion. The expected favorable formulation properties of these amphiphilic compounds should facilitate efforts to transform them into tools for biomedical research and perhaps as therapeutic agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.