ArticleProceedings of the National Academy of Sciences of the United States of America1991
Immunoglobulin variable-region-like domains of diverse sequence within the major histocompatibility complex of the chicken.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 68 citations in OpenAlex.
- Innate immune genes of the chicken MHC and related regions.Immunogenetics · 2022Review
- Fourth Report on Chicken Genes and Chromosomes 2022.Cytogenetic and genome research · 2022Review
- Functional Alleles of Chicken BG Genes, Members of the Butyrophilin Gene Family, in Peripheral T Cells.Frontiers in immunology · 2018Article
- Article
- Brief review of the chicken Major Histocompatibility Complex: the genes, their distribution on chromosome 16, and their contributions to disease resistance.Poultry science · 2016Review
- Sequence of a complete chicken BG haplotype shows dynamic expansion and contraction of two gene lineages with particular expression patterns.PLoS genetics · 2014Article
- Identification of key genes in the response to Salmonella enterica Enteritidis, Salmonella enterica Pullorum, and poly(I:C) in chicken spleen and caecum.BioMed research international · 2014Article
- Extended sequence of the turkey MHC B-locus and sequence variation in the highly polymorphic B-G loci.Immunogenetics · 2011Article
- Characterisation of a cluster of TRIM-B30.2 genes in the chicken MHC B locus.Immunogenetics · 2005Article
- 2004 Nomenclature for the chicken major histocompatibility (B and Y) complex.Immunogenetics · 2004Review
- Structural organization and mammary-specific expression of the butyrophilin gene.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Characterization of Mhc genes in a multigenerational family of ring-necked pheasants.Immunogenetics · 1996Article
- Two Mhc class I and two Mhc class II genes map to the chicken Rfp-Y system outside the B complex.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Evolutionary study of multigenic families mapping close to the human MHC class I region.Journal of molecular evolution · 1993Article
- Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Connections between the immune system and the nervous system.Proceedings of the National Academy of Sciences of the United States of America · 1993Review
- Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway.Molecular and cellular biology · 1993Article
- A polymorphic system related to but genetically independent of the chicken major histocompatibility complex.Immunogenetics · 1993Article
- Cloning and expression of chicken erythrocyte transglutaminase.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1992Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The highly polymorphic B-G antigens are considered to be part of the major histocompatibility complex (MHC) of the chicken, the B system of histocompatibility, because they are encoded in a family of genes tightly linked with the genes encoding MHC class I and class II antigens. To better understand these unusual MHC antigens, full-length B-G cDNA clones were isolated from B21 embryonic erythroid cell cDNA library, restriction-mapped, and sequenced. Five transcript types were identified. Analysis of the deduced amino acid sequences suggests that the B-G polypeptides are composed of single extracellular domains that resemble immunoglobulin domains of the variable-region (V) type, single membrane-spanning domains typical of integral membrane proteins, and long cytoplasmic tails. Sequence diversity among the five transcript types was found in all domains, notably including the B-G immunoglobulin V-like domains. The cytoplasmic tails of the B-G antigens are made up entirely of units of seven amino acid residues (heptads) that are typical of an alpha-helical coiled-coil conformation. The heptads vary in number and sequence between the different transcripts. The presence within B-G polypeptides of polymorphic immunoglobulin V-like domains warrants further investigations to determine the degree and nature of variability within this domain in these unusual MHC antigens.
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