ArticleEndocrine pathology2008
Expression of Wnt4 in human pituitary adenomas regulates activation of the beta-catenin-independent pathway.
Article in Endocrine pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Gene expression in prolactinomas: a systematic review.Pituitary · 2016Pooled it
- Review
- Pituitary Tumorigenesis-Implications for Management.Medicina (Kaunas, Lithuania) · 2023Review
- Phosphorylation of β-catenin at Serine552 correlates with invasion and recurrence of non-functioning pituitary neuroendocrine tumours.Acta neuropathologica communications · 2022Article
- PRMT5/Wnt4 axis promotes lymph-node metastasis and proliferation of laryngeal carcinoma.Cell death & disease · 2020Article
- Differential circular RNA expression profiles of invasive and non-invasive non-functioning pituitary adenomas: A microarray analysis.Medicine · 2019Article
- Exosomes Derived from Hypoxic Colorectal Cancer Cells Transfer Wnt4 to Normoxic Cells to Elicit a Prometastatic Phenotype.International journal of biological sciences · 2018Article
- Exosomes Derived From Hypoxic Colorectal Cancer Cells Promote Angiogenesis Through Wnt4-Induced β-Catenin Signaling in Endothelial Cells.Oncology research · 2017Article
- The Stem Cell Connection of Pituitary Tumors.Frontiers in endocrinology · 2017Article
- Molecular cloning, characterization and expression analysis of Frizzled 6 in the small intestine of pigs (Sus scrofa).PloS one · 2017Article
- Pituitary adenomas: historical perspective, surgical management and future directions.CNS oncology · 2015Review
- Article
- Wnt4 inhibits cell motility induced by oncogenic Ras.Oncogene · 2013Article
- Frizzled homolog proteins, microRNAs and Wnt signaling in cancer.International journal of cancer · 2013Review
- Components of the canonical and non-canonical Wnt pathways are not mis-expressed in pituitary tumors.PloS one · 2013Article
- Wnt pathway activity confers chemoresistance to cancer stem-like cells in a neuroblastoma cell line.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Effects of fulvestrant on biological activity and Wnt expression in rat GH3 cells.Neural regeneration research · 2012Article
- WNT10A plays an oncogenic role in renal cell carcinoma by activating WNT/β-catenin pathway.PloS one · 2012Article
- Pathogenesis of pituitary tumors.Nature reviews. Endocrinology · 2011Review
- An RNA interference-based screen of transcription factor genes identifies pathways necessary for sensory regeneration in the avian inner ear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Wnt signaling pathway has been implicated in the genesis of numerous human cancers. A member of the Wnt family of genes, Wnt4, has been known to regulate proliferation of anterior pituitary cell types in the mouse during embryonic development. In order to elucidate the roles of Wnt signaling in human pituitary adenomas, we examined the expression of Wnt4 and its putative receptor Frizzled6 (Fzd6) by immunohistochemistry in pituitary adenomas and normal pituitaries. Expression of Wnt4 was higher in growth hormone-producing adenomas (GHomas), prolactin-producing adenomas (PRLomas), and thyroid-stimulating hormone-producing adenomas (TSHomas) than in the normal pituitary. Fzd6 was widely expressed in GHomas, PRLomas, TSHomas, and gonadotropin subunit (GnSU)-positive adenomas. In normal pituitary glands, Wnt4 and Fzd6 were colocalized predominantly in follicle-stimulating hormone-, luteinizing hormone-, and alpha-subunits of glycoprotein hormone-positive cells. The canonical Wnt/beta-catenin signaling pathway was analyzed by beta-catenin immunohistochemistry. beta-Catenin was localized at the cell membrane in all pituitary adenomas, but not in the nuclei. On the other hand, Erk1/2 was highly activated in GHomas and TSHomas. These results suggested that activation of Wnt4/Fzd6 signaling through a "beta-catenin-independent" pathway played a role in proliferation and survival of the pituitary adenoma cells. Detailed involvement of transcription factors including Pit-1 remains to be further investigated.
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