ArticleCell biochemistry and biophysics2009
Temperature-dependent activation of neurons by continuous near-infrared laser.
Article in Cell biochemistry and biophysics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Thermophoresis induced by photothermal shock alters reversal potential and capacitance in neurons.Biophysical journal · 2026Article
- Thermal effects and ephaptic entrainment in Hodgkin-Huxley model.Scientific reports · 2024Article
- Modulation of neuronal dynamics by sustained and activity-dependent continuous-wave near-infrared laser stimulation.Neurophotonics · 2024Article
- Serum potassium changes during hypothermia and rewarming: a case series and hypothesis on the mechanism.Clinical kidney journal · 2023Article
- Contactless and spatially structured cooling by directing thermal radiation.Scientific reports · 2021Article
- Model study of combined electrical and near-infrared neural stimulation on the bullfrog sciatic nerve.Lasers in medical science · 2017Article
- A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1.Nature communications · 2015Article
- Article
- Photoactivation of neurons by laser-generated local heating.AIP advances · 2012Article
- Heteromeric heat-sensitive transient receptor potential channels exhibit distinct temperature and chemical response.The Journal of biological chemistry · 2012Article
- Thermosensitive TRP channel pore turret is part of the temperature activation pathway.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Optical control of neuronal activity has a number of advantages over electrical methods and can be conveniently applied to intact individual neurons in vivo. In this study, we demonstrated an experimental approach in which a focused continuous near-infrared (CNI) laser beam was used to activate single rat hippocampal neurons by transiently elevating the local temperature. Reversible changes in the amplitude and kinetics of neuronal voltage-gated Na and K channel currents were recorded following irradiation with a single-mode 980 nm CNI-laser. Using single-channel recordings under controlled temperatures as a means of calibration, it was estimated that temperature at the neuron rose by 14 degrees C in 500 ms. Computer simulation confirmed that small temperature changes of about 5 degrees C were sufficient to produce significant changes in neuronal excitability. The method should be broadly applicable to studies of neuronal activity under physiological conditions, in particular studies of temperature-sensing neurons expressing thermoTRP channels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.