Trial reportClinical oral investigations2009
Comparison of the immediate effects of gaseous ozone and chlorhexidine gel on bacteria in cavitated carious lesions in children in vivo.
Trial report in Clinical oral investigations, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 44 citations in OpenAlex.
- Influence of ozone application in the stepwise excavation of primary molars: a randomized clinical trial.Clinical oral investigations · 2020Trial
- Effectiveness of the ozone application in two-visit indirect pulp therapy of permanent molars with deep carious lesion: a randomized clinical trial.Clinical oral investigations · 2019Trial
- Clinical antibacterial effectiveness and biocompatibility of gaseous ozone after incomplete caries removal.Clinical oral investigations · 2019Trial
- Ozone Treatment for the Management of Caries in Primary Dentition: A Systematic Review of Clinical Studies.Dentistry journal · 2024Review
- Enhancing the Antimicrobial Effect of Ozone withMolecules (Basel, Switzerland) · 2023Article
- Efficacy of antiseptics and chemomechanical methods for dentin caries lesions: A systematic review with GRADE approach.Frontiers in oral health · 2023Review
- Antimicrobial Effect of Ozone Therapy in Deep Dentinal Carious Lesion: A Systematic Review.International journal of clinical pediatric dentistry · 2022Review
- Application of Selected Nanomaterials and Ozone in Modern Clinical Dentistry.Nanomaterials (Basel, Switzerland) · 2021Review
- Chlorhexidine Gel Use in the Oral District: A Systematic Review.Gels (Basel, Switzerland) · 2019Review
- Treatment effect of ozone and fluoride varnish application on occlusal caries in primary molars: a 12-month study.Clinical oral investigations · 2014Article
- Influence of gaseous ozone in peri-implantitis: bactericidal efficacy and cellular response. An in vitro study using titanium and zirconia.Clinical oral investigations · 2012Article
- XTT assay of ex vivo saliva biofilms to test antimicrobial influences.GMS Krankenhaushygiene interdisziplinar · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical application of ozone gas has been shown to arrest the progression of dentinal caries in children. In this study, we compare the immediate effects of gaseous ozone and chlorhexidine gel on bacteria in cavitated carious lesions in children. Forty children, each with at least two open occlusal carious lesions, were enrolled in the study. Two teeth were chosen randomly. In one lesion, overlying soft biological material was removed, whilst the other lesion was not excavated. Cavities were rinsed with sterile water and dried with air. A standardised sample was taken from the mesial part of each lesion. Then, gaseous ozone (HealOzone) or 1% chlorhexidine gel (Corsodyl) was applied for 30 s on both lesions of 20 children each, and a second sample was taken from the distal part of each lesion. The anaerobic microbiota was cultivated; the number of colony forming units was calculated per milligram sample. The two-sided paired t test showed no significant (P > 0.05) differences in the reduction of total bacterial counts per milligram comparing samples before and after ozone or chlorhexidine application. The tests also showed no statistically significant difference whether the superficial decayed dentine had been removed before ozone or with chlorhexidine treatment or not. It can be concluded that gaseous ozone or chlorhexidine gel application for 30 s to deep occlusal carious cavities had no significant immediate antimicrobial effects whether the superficial decayed layers dentine were removed or not.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.