Evidence map›Paper›PMID 19034437›Full record

ArticleExperimental brain research2009

L-type Ca2+ current in frog tectal recurrent neurons determines the NMDA receptor activation on efferent neuron.

Armantas Baginskas, Antanas Kuras

Abstract read
PubMed Publisher
In one paragraph

Article in Experimental brain research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Armantas BaginskasLaboratory of Neurophysiology, Institute for Biomedical Research, Kaunas University of Medicine, Eiveniu 4, 50009 Kaunas, Lithuania.
Antanas Kuras
Kaunas University of Technology · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The activity patterns of a neuronal network originate from the intrinsic properties and synaptic interactions of the constituent neurons. Our recent studies support this view, showing that the discharge of a single frog retina ganglion cell brings an elementary neuronal network of the tectum (tectum column) to a suprathreshold activity of two distinct levels that are related to the activation of the slow L-type calcium current in dendrites of the recurrent pear-shaped neurons (lower level) and the NMDA receptors in neurons (higher level) of the tectum column. We show in the present study that the dendritic slow L-type calcium current is necessary for the NMDA receptor activation in the tectum column. A small decrease of this current prevents the NMDA receptor activation and, hence, the transition of the network to the higher activity level, at which the efferent neuron of the network fires. So, the activity of the frog tectum column can be effectively controlled through the intrinsic properties of the recurrent pear-shaped neurons of the column.

Indexed as

2-Amino-5-phosphonovalerateAction PotentialsAnimalsCalcium Channel BlockersCalcium Channels, L-TypeDendritesElectric StimulationExcitatory Amino Acid AntagonistsMicroelectrodesNeurons, EfferentNifedipineRana temporariaReceptors, N-Methyl-D-AspartateRetinal Ganglion CellsTectum Mesencephali2-Amino-5-phosphonovalerateCalcium Channel BlockersCalcium Channels, L-TypeExcitatory Amino Acid AntagonistsNifedipineReceptors, N-Methyl-D-Aspartate

Identifiers

PMID19034437
OpenAlexW2101966082

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.