Trial reportBritish journal of cancer2008
No socioeconomic inequalities in colorectal cancer survival within a randomised clinical trial.
Trial report in British journal of cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- A systematic review of geographical differences in management and outcomes for colorectal cancer in Australia.BMC cancer · 2017Pooled it
- Impact of socioeconomic deprivation in patients undergoing elective surgical resection for colon cancer.BJS open · 2025Article
- Inequalities in treatment among patients with colon and rectal cancer: a multistate survival model using data from England national cancer registry 2012-2016.British journal of cancer · 2024Article
- Socioeconomic disparities in colorectal cancer survival: contributions of prognostic factors in a large Australian cohort.Journal of cancer research and clinical oncology · 2022Article
- Low Socioeconomic Status Is Associated with Worse Outcomes After Curative Surgery for Colorectal Cancer: Results from a Large, Multicenter Study.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020Article
- Geographical variations in cancer mortality and social inequalities in southern Spain (Andalusia). 2002-2013.PloS one · 2020Article
- Understanding the impact of socioeconomic differences in colorectal cancer survival: potential gain in life-years.British journal of cancer · 2019Article
- Persistent inequalities in 90-day colon cancer mortality: an English cohort study.British journal of cancer · 2017Article
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- The impact of age at diagnosis on socioeconomic inequalities in adult cancer survival in England.Cancer epidemiology · 2015Article
- Socioeconomic inequalities in relative survival of rectal cancer most obvious in stage III.World journal of surgery · 2014Article
- No socioeconomic inequalities in ovarian cancer survival within two randomised clinical trials.British journal of cancer · 2014Article
- Advanced testicular cancer in a society of racial and socio-economic health disparity.BMJ case reports · 2013Article
- Socioeconomic inequalities in cancer survival in England after the NHS cancer plan.British journal of cancer · 2010Article
- Trends and variation in the management of oesophagogastric cancer patients: a population-based survey.BMC health services research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
There is strong evidence that colorectal cancer survival differs between socioeconomic groups. We analysed data on 2481 patients diagnosed during 1989-1997 and recruited to a randomised controlled clinical trial (AXIS, ISRCTN32414363) of chemotherapy and radiotherapy for colorectal cancer. Crude and relative survival at 1 and 5 years was estimated in five categories of socioeconomic deprivation. Multiple imputation was used to account for missing data on tumour stage. A multivariable fractional polynomial model was fitted to estimate the excess hazard of death in each deprivation category, adjusting for the confounding effects of age, stage, cancer site (colon, rectum) and sex, using generalised linear models. Relative survival in the trial patients was higher than in the general population of England and Wales. The socioeconomic gradient in survival was much smaller than that seen for colorectal cancer patients in the general population, both at 1 year -3.2% (95% CI -7.3 to 1.0%, P=0.14) and at 5 years -1.7% (95% CI -8.3 to 4.9%, P=0.61). Given equal treatment, colorectal cancer survival in England and Wales does not appear to depend on socioeconomic status, suggesting that the socioeconomic gradient in survival in the general population could well be due to health-care system factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.