ArticleBritish journal of cancer2009
Helicobacter species in cancers of the gallbladder and extrahepatic biliary tract.
Article in British journal of cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 58 citations in OpenAlex.
- Gallbladder Cancer: Epidemiology and Prevention.Cancers · 2026Review
- Gut Microbiota: A Potential Role in Modulating Carcinogenesis and Response to Anti-Cancer Therapies.Cancer reports (Hoboken, N.J.) · 2026Review
- Microbial Landscapes of the Gut-Biliary Axis: Implications for Benign and Malignant Biliary Tract Diseases.Microorganisms · 2025Review
- Is cross-species horizontal gene transfer responsible for gallbladder carcinogenesis.World journal of surgical oncology · 2024Article
- Unraveling the intricate relationship: Influence of microbiome on the host immune system in carcinogenesis.Cancer reports (Hoboken, N.J.) · 2023Review
- Bacteria and macrophages in the tumor microenvironment.Frontiers in microbiology · 2023Review
- Metagenomic Sequencing of the Gallbladder Microbiome: Bacterial Diversity Does Not Vary by Surgical Pathology.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Article
- The Role of Gut Microbiota in Gastrointestinal Tract Cancers.Archivum immunologiae et therapiae experimentalis · 2022Review
- Prevalence estimates of Helicobacter species infection in pancreatic and biliary tract cancers.Helicobacter · 2022Article
- Association of Microbial Dysbiosis with Gallbladder Diseases Identified by Bile Microbiome Profiling.Journal of Korean medical science · 2021Article
- Roles of Salmonella typhi and Salmonella paratyphi in Gallbladder Cancer Development.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Decipher the Helicobacter pylori Protein Targeting in the Nucleus of Host Cell and their Implications in Gallbladder Cancer: AnJournal of Cancer · 2021Article
- Associations between Helicobacter pylori with nonalcoholic fatty liver disease and other metabolic conditions in Guatemala.Helicobacter · 2020Article
- Article
- The Bacterial Microbiota of Gastrointestinal Cancers: Role in Cancer Pathogenesis and Therapeutic Perspectives.Clinical and experimental gastroenterology · 2020Review
- Studying the effects of several heat-inactivated bacteria on colon and breast cancer cells.Molecular biology research communications · 2019Article
- Linking Helicobacter pylori with gallbladder and biliary tract cancer in Moroccan population using clinical and pathological profiles.Bioinformation · 2019Article
- Microbiota in cancer development and treatment.Journal of cancer research and clinical oncology · 2019Review
- Plasma Helicobacter pylori Antibody Titers and Helicobacter pylori Infection Positivity Rates in Patients with Gallbladder Cancer or Cholelithiasis: a Hospital-Based Case-Control StudyAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Metagenomics of Microbial Communities in Gallbladder Bile from Patients with Gallbladder Cancer or CholelithiasisAsian Pacific journal of cancer prevention : APJCP · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter species have been found in human bile and biliary tract (BT) tissue and are suspected to cause BT diseases, including gallbladder and extrahepatic cancers, collectively referred to in this work as BT cancers. We conducted a literature review of the epidemiological evidence linking the presence of Helicobacter species in bile or BT biopsies to BT cancers and benign diseases. Reports showed great variability with respect to study methods. Nine studies of BT cancers were identified, all with 30 or fewer BT cancers; eight included cancer-free control subjects and used polymerase chain reaction (PCR) as a means of Helicobacter species detection. In four of these studies, Helicobacter species were detected in patients with BT cancer significantly more frequently than in controls, at least when controls without BT diseases were used. In two studies, no Helicobacter species were detected in either cases or controls. Helicobacter species were also often detected in benign BT diseases such as gallstone disease or chronic cholecystitis. As our current knowledge relies on a few small studies that showed substantial differences, larger studies and more standardised protocols for detecting DNA and antibodies against Helicobacter species are needed to investigate a potential association with BT cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.