ArticleThe Journal of clinical investigation2008
Prostacyclin primes pregnant human myometrium for an enhanced contractile response in parturition.
Article in The Journal of clinical investigation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Prostacyclin Assists in the Repair of Ruptured Amnions through the Proliferation and Migration of Amnion Mesenchymal Cells.The American journal of pathology · 2025Article
- Prostacyclin enlists AC6 to stop the clot.Journal of thrombosis and haemostasis : JTH · 2025Article
- Urinary prostaglandin metabolites as biomarkers for human labour: Insights into future predictors.PloS one · 2025Article
- Uterine injury during diestrus leads to placental and embryonic defects in future pregnancies in mice†.Biology of reproduction · 2024Article
- Article
- Prostacyclin Synthesis and Prostacyclin Receptor Expression in the Porcine Myometrium: Prostacyclin Potential to Regulate Fatty Acid Transporters, Cytokines and Contractility-Related Factors.Animals : an open access journal from MDPI · 2022Article
- PKA and AKIP1 interact to mediate cAMP-driven COX-2 expression: A potentially pivotal interaction in preterm and term labour.PloS one · 2021Article
- Maternal obesity-induced decreases in plasma, hepatic and uterine polyunsaturated fatty acids during labour is reversed through improved nutrition at conception.Scientific reports · 2018Article
- Prostaglandin-Endoperoxide Synthase 1 Mediates the Timing of Parturition in Mice Despite Unhindered Uterine Contractility.Endocrinology · 2018Article
- Ryanodine receptor type 3 does not contribute to contractions in the mouse myometrium regardless of pregnancy.Pflugers Archiv : European journal of physiology · 2017Article
- Differential impact of acute and prolonged cAMP agonist exposure on protein kinase A activation and human myometrium contractile activity.The Journal of physiology · 2016Article
- Effect of propofol on prostaglandin E2 production and prostaglandin synthase-2 and cyclooxygenase-2 expressions in amniotic membrane cells.Journal of anesthesia · 2014Article
- The physiological roles of placental corticotropin releasing hormone in pregnancy and childbirth.Journal of physiology and biochemistry · 2013Review
- Azithromycin prevents pregnancy loss: reducing the level of tumor necrosis factor-alpha and raising the level of interleukin-10 in rats.Mediators of inflammation · 2013Article
- Cyclic AMP increases COX-2 expression via mitogen-activated kinase in human myometrial cells.Journal of cellular and molecular medicine · 2012Article
- Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn.Pharmacological reviews · 2012Review
- Vascular smooth muscle phenotypic diversity and function.Physiological genomics · 2010Review
- Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term.Journal of perinatal medicine · 2010Article
- Dual effect of nitric oxide on uterine prostaglandin synthesis in a murine model of preterm labour.British journal of pharmacology · 2010Article
- Myometrial interstitial cells and the coordination of myometrial contractility.Journal of cellular and molecular medicine · 2009Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
An incomplete understanding of the molecular events that regulate the myometrial transition from the quiescent pregnant state to the active contractile state during labor has hindered the development of improved therapies for preterm labor. During myometrial activation, proteins that prime the smooth muscle for contraction are upregulated, allowing maximal responsiveness to contractile agonists and thereby producing strong phasic contractions. Upregulation of one such protein, COX-2, generates PGs that induce contractions. Intriguingly, the predominant myometrial PG produced just prior to labor is prostacyclin (PGI2), a smooth muscle relaxant. However, here we have shown that activation of PGI2 receptor (IP) upregulated the expression of several contractile proteins and the gap junction protein connexin 43 through cAMP/PKA signaling in human myometrial tissue in organ and cell culture. Functionally, these IP-dependent changes in gene expression promoted an enhanced contractile response to oxytocin in pregnant human myometrial tissue strips, which was inhibited by the IP antagonist RO3244794. Furthermore, contractile protein induction was dependent on the concentration and time of exposure to the PGI2 analog iloprost and was blocked by both RO3244794 and PKA knockdown. We therefore propose that PGI2-mediated upregulation of contractile proteins and connexin 43 is a critical step in myometrial activation, allowing for a maximal contractile response. Our observations have important implications regarding activation of the myometrium prior to the onset of labor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.