ArticleThe Journal of clinical investigation2008
Cystic fibrosis and estrogens: a perfect storm.
Article in The Journal of clinical investigation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- The impact of perfusate filtration or exchange on lung function during ex vivo lung perfusion (EVLP): a systematic review.Journal of thoracic disease · 2026Review
- Sex, hormones, and lung health.Physiological reviews · 2026Review
- Changes of androgen and corticosterone metabolites excretion and conversion in cystic fibrosis.Frontiers in endocrinology · 2023Article
- A model for building a national, patient-driven database to track contraceptive use in women with rare diseases.Journal of the American Medical Informatics Association : JAMIA · 2022Article
- Review
- Research advances in molecular mechanisms underlying the pathogenesis of cystic fibrosis: From technical improvement to clinical applications (Review).Molecular medicine reports · 2020Review
- An Intriguing Involvement of Mitochondria in Cystic Fibrosis.Journal of clinical medicine · 2019Review
- Gender differences in bronchiectasis: a real issue?Breathe (Sheffield, England) · 2018Review
- Ion channels of the lung and their role in disease pathogenesis.American journal of physiology. Lung cellular and molecular physiology · 2017Review
- Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol.Scientific reports · 2017Article
- Role of epithelial sodium channels in the regulation of lung fluid homeostasis.American journal of physiology. Lung cellular and molecular physiology · 2015Review
- Risk factors for lung function decline in a large cohort of young cystic fibrosis patients.Pediatric pulmonology · 2015Observational
- Subcutaneous implant with etonogestrel (Implanon®) for catamenial exacerbations in a patient with cystic fibrosis: a case report.BMC pulmonary medicine · 2014Article
- Longevity of patients with cystic fibrosis in 2000 to 2010 and beyond: survival analysis of the Cystic Fibrosis Foundation patient registry.Annals of internal medicine · 2014Article
- Estradiol activates epithelial sodium channels in rat alveolar cells through the G protein-coupled estrogen receptor.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Barrier function of airway tract epithelium.Tissue barriers · 2013Review
- Repair and Remodeling of airway epithelium after injury in Chronic Obstructive Pulmonary Disease.Current respiratory care reports · 2013Article
- Sex hormone-dependent regulation of cilia beat frequency in airway epithelium.American journal of respiratory cell and molecular biology · 2012Article
- Association between socioeconomic status, sex, and age at death from cystic fibrosis in England and Wales (1959 to 2008): cross sectional study.BMJ (Clinical research ed.) · 2011Article
- Socio-economic factors and outcomes in chronic lung disease of prematurity.Pediatric pulmonology · 2011Article
Corrections and comments
- Comment on
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Irreversible destruction and widening of the airways due to acquired infections or genetic mutations as well as those of unknown cause are more severe in females. Differences between male and female anatomy, behavior, and hormonal state have been proposed to explain the increased incidence and severity in females with airway disease such as cystic fibrosis (CF); however, a mechanism to explain a sex-related difference has remained elusive. In this issue of the JCI, Coakley et al. report that elevations in the major estrogen hormone in humans--17beta-estradiol--reduce Ca2+-activated Cl- secretion by airway epithelial cells in culture, thereby disrupting ion and water balance (see the related article beginning on page 4025). They measure a similar diminution of nasal epithelial Ca2+-activated Cl- secretion in women with CF during the menstrual cycle phase at which 17beta-estradiol level is at its highest. These data suggest that for about one week of a four-week menstrual cycle, women with CF will have a reduced ability to efficiently clear airway secretions, the buildup of which is a hallmark of CF. The authors suggest that these data warrant the testing of antiestrogen therapy in females with CF and propose an alternative avenue for CF therapeutic development.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.