ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2009
Protective role of angiotensin II type 2 receptor signaling in a mouse model of pancreatic fibrosis.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Eosinophilic Esophagitis: Cytokines Expression and Fibrotic Markers in Comparison to Celiac Disease.Diagnostics (Basel, Switzerland) · 2022Article
- Angiotensin receptor signaling and prostate tumor growth in mice.Journal of experimental therapeutics & oncology · 2017Article
- The angiotensin II type 2 receptor agonist Compound 21 is protective in experimental diabetes-associated atherosclerosis.Diabetologia · 2016Article
- Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in Mice.Cellular and molecular gastroenterology and hepatology · 2016Article
- Article
- International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected].Pharmacological reviews · 2015Review
- Differences in the degree of cerulein-induced chronic pancreatitis in C57BL/6 mouse substrains lead to new insights in identification of potential risk factors in the development of chronic pancreatitis.The American journal of pathology · 2013Article
- Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels.Nature communications · 2013Article
- The role of stroma in pancreatic cancer: diagnostic and therapeutic implications.Nature reviews. Gastroenterology & hepatology · 2012Review
- Review article: the pathophysiological roles of the renin-angiotensin system in the gastrointestinal tract.Alimentary pharmacology & therapeutics · 2012Review
- The Angiotensin II Type 2 Receptor in Brain Functions: An Update.International journal of hypertension · 2012Article
- Transforming growth factor beta signaling in adult cardiovascular diseases and repair.Cell and tissue research · 2012Review
- Pigment epithelium-derived factor regulates early pancreatic fibrotic responses and suppresses the profibrotic cytokine thrombospondin-1.The American journal of pathology · 2011Article
- LOX-1 and angiotensin receptors, and their interplay.Cardiovascular drugs and therapy · 2011Review
- Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism.Science (New York, N.Y.) · 2011Article
- New insights into angiotensin receptor actions: from blood pressure to aging.Current opinion in nephrology and hypertension · 2011Review
- Angiotensin II signaling through the AT1a and AT1b receptors does not have a role in the development of cerulein-induced chronic pancreatitis in the mouse.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Angiotensin II type 2 receptor signaling significantly attenuates growth of murine pancreatic carcinoma grafts in syngeneic mice.BMC cancer · 2010Article
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Authors and funding
5 authors.
Funding
Abstract
The renin-angiotensin system contributes to pathological processes in a variety of organs. In the pancreas, blocking the angiotensin II (AII) type 1 receptor (AT1) attenuates pancreatic fibrogenesis in animal models of pancreatitis. Because the role of the AII type 2 receptor (AT2) in modulating pancreatic injury is unknown we investigated the role of AT2 in pancreatic injury and fibrosis. Pancreatic fibrosis was induced by repetitive cerulein administration in C57BL/6 wild-type (WT) or AT2-deficient (AT2-/-) mice and assessed by morphology and gene expression at 10 days. There was no difference between WT and AT2-/- mice in the degree of acute pancreatic injury as assessed by amylase release at 9 and 12 h and by histological examination of the pancreas at 12 h. In contrast, parenchymal atrophy and fibrosis were more pronounced in AT2-/- mice compared with WT mice at 10 days. Fibrosis was accompanied by activation of pancreatic stellate cells (PSC) evaluated by Western blot analysis for alpha-smooth muscle actin and by immunocytochemistry; PSC activation was further increased in AT2-/- mice compared with WT mice. The level of pancreatic transforming growth factor-beta1 mRNA and protein after repetitive cerulein treatment was higher in AT2-/- mice than in WT mice. Our results demonstrate that, in contrast to AT1 receptor signaling, AT2 receptor signaling modulates protective antifibrogenic effects in a mouse model of cerulein-induced pancreatic fibrogenesis. We propose that the effects of AII on injury-induced pancreatic fibrosis may be determined by the balance between AT1 and AT2 receptor signaling.
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