Trial reportAmerican journal of physiology. Gastrointestinal and liver physiology2009
Effect of a chloride channel activator, lubiprostone, on colonic sensory and motor functions in healthy subjects.
Trial report in American journal of physiology. Gastrointestinal and liver physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Lubiprostone, a Chloride Channel Activator, on Colonic Sensorimotor Functions in Healthy Subjects. A Phase IV, Placebo-Controlled, Parallel Group Study
Efficacy and Safety of Lubiprostone in the Treatment of Slow Transit Constipation: A Multicenter, Randomized Controlled Trial
Who cites it
28 citing papers in PubMed, 70 citations in OpenAlex.
- Lubiprostone does not influence visceral pain thresholds in patients with irritable bowel syndrome.Neurogastroenterology and motility · 2011Trial
- Effects of bisacodyl on ascending colon emptying and overall colonic transit in healthy volunteers.Alimentary pharmacology & therapeutics · 2009Trial
- Review
- Article
- Targeting Small Bowel Receptors to Treat Constipation and Diarrhea.Current gastroenterology reports · 2017Review
- Lubiprostone improves visualization of small bowel for capsule endoscopy: a double-blind, placebo-controlled 2-way crossover study.Endoscopy international open · 2017Article
- Management of chronic constipation in patients with diabetes mellitus.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2017Review
- Efficacy and Safety of Prucalopride in Chronic Constipation: An Integrated Analysis of Six Randomized, Controlled Clinical Trials.Digestive diseases and sciences · 2016Article
- Prokinetic effects of large-dose lubiprostone on gastrointestinal transit in dogs and its mechanisms.American journal of translational research · 2015Article
- The use of non-narcotic pain medication in pediatric gastroenterology.Paediatric drugs · 2014Review
- Complementary and alternative medicines in irritable bowel syndrome: an integrative view.World journal of gastroenterology · 2014Review
- Open channels for functional bowel disorders: guanylate cyclase C agonists in IBS and CC.Digestive diseases and sciences · 2013Article
- American Gastroenterological Association technical review on constipation.Gastroenterology · 2013Review
- Drug development for the irritable bowel syndrome: current challenges and future perspectives.Frontiers in pharmacology · 2013Article
- Lubiprostone targets prostanoid signaling and promotes ion transporter trafficking, mucus exocytosis, and contractility.Digestive diseases and sciences · 2012Article
- Lubiprostone for the treatment of adult women with irritable bowel syndrome with constipation.Clinical medicine insights. Gastroenterology · 2012Review
- New treatment options for chronic constipation: mechanisms, efficacy and safety.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2011Review
- Lubiprostone for the treatment of adults with constipation and irritable bowel syndrome.Digestive diseases and sciences · 2011Review
- Current management strategies and therapeutic targets in chronic constipation.Therapeutic advances in gastroenterology · 2011Article
- Lubiprostone: evaluation of the newest medication for the treatment of adult women with constipation-predominant irritable bowel syndrome.International journal of women's health · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Lubiprostone, a bicyclic fatty acid chloride channel activator, is efficacious in treatment of chronic constipation and constipation-predominant irritable bowel syndrome. The study aim was to compare effects of lubiprostone and placebo on colonic sensory and motor functions in humans. In double-blind, randomized fashion, 60 healthy adults received three oral doses of placebo or 24 microg lubiprostone per day in a parallel-group, placebo-controlled trial. A barostat-manometry tube was placed in the left colon by flexible sigmoidoscopy and fluoroscopy. We measured treatment effects on colonic sensation and motility with validated methods, with the following end points: colonic compliance, fasting and postprandial tone and motility indexes, pain thresholds, and sensory ratings to distensions. Among participants receiving lubiprostone or placebo, 26 of 30 and 28 of 30, respectively, completed the study. There were no overall effects of lubiprostone on compliance, fasting tone, motility indexes, or sensation. However, there was a treatment-by-sex interaction effect for compliance (P = 0.02), with lubiprostone inducing decreased fasting compliance in women (P = 0.06) and an overall decreased colonic tone contraction after a standard meal relative to fasting tone (P = 0.014), with greater effect in women (P < 0.01). Numerical differences of first sensation and pain thresholds (P = 0.11 in women) in the two groups were not significant. We concluded that oral lubiprostone 24 microg does not increase colonic motor function. The findings of decreased colonic compliance and decreased postprandial colonic tone in women suggest that motor effects are unlikely to cause accelerated colonic transit with lubiprostone, although they may facilitate laxation. Effects of lubiprostone on sensitivity deserve further study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.