ArticleThe Plant cell2008
Independent losses of function in a polyphenol oxidase in rice: differentiation in grain discoloration between subspecies and the role of positive selection under domestication.
Article in The Plant cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Birth and death evolution of polyphenol oxidase (PPO) gene family in Oryza species.Botanical studies · 2026Article
- Independent Origin of Phenol Non-responsive Phenotype Caused By Phr1 Variation During Domestication of Asian and African Rice.Rice (New York, N.Y.) · 2026Article
- Investigation and characterization of the GhPPO gene family and its expression in response to fibre cell growth and biotic stress in Gossypium hirsutum L.BMC genomics · 2025Article
- Structural Variations Contribute to Subspeciation and Yield Heterosis in Rice.Plant biotechnology journal · 2025Article
- Biochemical Analysis of Recombinant Pea Seed Coat-Specific Polyphenol Oxidase (Journal of agricultural and food chemistry · 2025Article
- Domestication Reduces Plant Immune Receptor Gene Repertoires Across Lineages.Genome biology and evolution · 2025Article
- Characterization of Indian waxy and non-waxy maize germplasm for genetic differentiation through SNP genotyping.Molecular genetics and genomics : MGG · 2025Article
- Defense-Related Enzyme Activities and Metabolomic Analysis Reveal Differentially Accumulated Metabolites and Response Pathways for Sheath Blight Resistance in Rice.Plants (Basel, Switzerland) · 2024Article
- Crop Evolution of Foxtail Millet.Plants (Basel, Switzerland) · 2024Review
- Genome-wide analysis of the polyphenol oxidase gene family reveals that MaPPO1 and MaPPO6 are the main contributors to fruit browning inFrontiers in plant science · 2023Article
- Multi-target genome editing reduces polyphenol oxidase activity in wheat (Frontiers in plant science · 2023Article
- Polyphenol oxidase genes in barley (Frontiers in plant science · 2023Article
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- A β-ketoacyl carrier protein reductase confers heat tolerance via the regulation of fatty acid biosynthesis and stress signaling in rice.The New phytologist · 2021Article
- RIL-StEp: epistasis analysis of rice recombinant inbred lines reveals candidate interacting genes that control seed hull color and leaf chlorophyll content.G3 (Bethesda, Md.) · 2021Article
- Extensive variation within the pan-genome of cultivated and wild sorghum.Nature plants · 2021Article
- Evolutionary Origins of Drought Tolerance in Spermatophytes.Frontiers in plant science · 2021Article
- Phenoloxidases in Plants-How Structural Diversity Enables Functional Specificity.Frontiers in plant science · 2021Review
- Whole-genome sequencing reveals uniqueness of black-hulled and straw-hulled weedy rice genomes.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asian rice (Oryza sativa) cultivars originated from wild rice and can be divided into two subspecies by several criteria, one of which is the phenol reaction (PHR) phenotype. Grains of indica cultivars turn brown in a phenol solution that accelerates a similar process that occurs during prolonged storage. By contrast, the grains of japonica do not discolor. This distinction may reflect the divergent domestication of these two subspecies. The PHR is controlled by a single gene, Phr1; here, we report the cloning of Phr1, which encodes a polyphenol oxidase. The Phr1 gene is indeed responsible for the PHR phenotype, as transformation with a functional Phr1 can complement a PHR negative cultivar. Phr1 is defective in all japonica lines but functional in nearly all indica and wild strains. Phylogenetic analysis showed that the defects in Phr1 arose independently three times. The multiple recent origins and rapid spread of phr1 in japonica suggest the action of positive selection, which is further supported by several population genetic tests. This case may hence represent an example of artificial selection driving the differentiation among domesticated varieties.
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