Evidence map›Paper›PMID 19033420›Full record

SynthesisDiabetes care2008

Depression and diabetes treatment nonadherence: a meta-analysis.

Jeffrey S Gonzalez, Mark Peyrot, Lauren A McCarl, Erin Marie Collins, Luis Serpa, Matthew J Mimiaga, Steven A Safren

Registry-linked trialAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Diabetes care, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04097483 (The TELE-DD Project), which is not on this map. Cited by 463 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
463citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04097483 nacompletednot on this mapstarted 2017, after this paper: background citation

The TELE-DD Project: a Nurse-led Randomised Controlled Trial on Treatment Adherence in Patients With Type 2 Diabetes and Comorbid Depression

TypeinterventionalSponsorAlicia Monreal BartoloméRan2017 to 2020Enrolled428ConditionsDiabetes Mellitus, Type 2, DepressionArmsTelephone Intervention Group
3 · Its place in the literature

Who cites it

463 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  9. Emotional distress, anxiety, and depression in South Asians with long-term conditions: a qualitative systematic review.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022
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  10. The bidirectional longitudinal association between depressive symptoms and HbADiabetic medicine : a journal of the British Diabetic Association · 2022
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403 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jeffrey S GonzalezBehavioral Medicine, Department of Psychiatry, Massachusetts General Hospital Boston, Boston, Massachusetts, USA. jsgonzalez@partners.org
Mark Peyrot
Lauren A McCarl
Erin Marie Collins
Luis Serpa
Matthew J Mimiaga
Steven A Safren

Funding

CBT for Adherence and Depression in DiabetesR01MH078571 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SAFREN, STEVEN A · 2006 to 2010
$1.8M
NIMH NIH HHS 1R01MH078571NIMH NIH HHS R01 MH078571
6 · The paper itself

Abstract

objectiveDepression is common in patients with diabetes and is associated with worse treatment outcomes. Its relationship to treatment adherence, however, has not been systematically reviewed. We used meta-analysis to examine the relationship between depression and treatment nonadherence in patients with type 1 and type 2 diabetes. RESEARCH DESIGN AND

methodsWe searched MEDLINE and PsycINFO databases for all studies published by June 2007 and reviewed references of published articles. Meta-analytic procedures were used to estimate the effect size r in a random effects model. Significance values, weighted effect sizes, 95% CIs, and tests of homogeneity of variance were calculated.

resultsResults from 47 independent samples showed that depression was significantly associated with nonadherence to the diabetes treatment regimen (z = 9.97, P < 0.0001). The weighted effect size was near the medium range (r = 0.21, 95% CI 0.17-0.25). Moderator analyses showed that the effect was significantly larger in studies that measured self-care as a continuous versus categorical variable (P = 0.001). Effect sizes were largest for missed medical appointments and composite measures of self-care (r values = 0.31, 0.29). Moderation analyses suggest that effects for most other types of self-care are also near the medium range, especially in studies with stronger methodologies.

conclusionsThese findings demonstrate a significant association between depression and treatment nonadherence in patients with diabetes. Studies that used stronger methodologies had larger effects. Treatment nonadherence may represent an important pathway between depression and worse diabetes clinical outcomes.

Indexed as

DepressionDiabetes MellitusHumansPatient ComplianceTreatment Refusal

Identifiers

PMID19033420
PMCPMC2584202

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.