Evidence map›Paper›PMID 19033403›Full record

ReviewDiabetes2008

The barrier of hypoglycemia in diabetes.

Philip E Cryer

3 registry-linked trialsOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diabetes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 297 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
297citing papers in PubMed, 5 pooled it
19.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02411578 phase2completednot on this mapstarted 2015, after this paper: background citation

Mini-Dose Glucagon for Adults With Type 1 Diabetes: A Study to Assess the Efficacy and Safety of Mini-dose Glucagon for Treatment of Non-severe Hypoglycemia in Adults With Type 1 Diabetes

TypeinterventionalSponsorJaeb Center for Health ResearchRan2015 to 2016Enrolled26ConditionsDiabetes Mellitus, Type 1ArmsG-Pen Mini™ (glucagon injection), Glucose Tablets
NCT02682940 naterminatednot on this mapstarted 2016, after this paper: background citation

Type I Diabetes Hypoglycemia Prevention Pilot Study

TypeinterventionalSponsorInSpark Technologies, Inc.Ran2016 to 2016Enrolled4ConditionsDiabetes Mellitus, Type 1, HypoglycemiaArmsVigilant Diabetes Management Application
NCT03161964 phase2terminatednot on this mapstarted 2017, after this paper: background citation

Propranolol as a Treatment for Impaired Awareness of Hypoglycemia in Type 1 Diabetes

TypeinterventionalSponsorAnu SharmaRan2017 to 2019Enrolled2ConditionsType 1 Diabetes MellitusArmsPropranolol 80 Mg Oral Capsule, Extended Release, Placebo oral capsule
3 · Its place in the literature

Who cites it

297 citing papers in PubMed, 5 syntheses or guidelines pooled it, 721 citations in OpenAlex.

  1. Pooled it
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  3. Guideline
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  6. Trial
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  12. Hypoglycaemia is reduced with use of inhaled TechnosphereDiabetic medicine : a journal of the British Diabetic Association · 2020
    Trial
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  19. Home Use of an Artificial Beta Cell in Type 1 Diabetes.The New England journal of medicine · 2015
    Trial
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237 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Philip E CryerDivision of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, MO, USA. pcryer@wustl.edu
Washington University in St. Louis · US

Funding

Washington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
YOGA FOR THE MANAGEMENT OF HIV-METABOLIC SYNDROMESM01RR000036 · NCRR · WASHINGTON UNIVERSITY · PI NEWCOMER, JOHN W. · 1985 to 2007
$25.4M
TRANSGENICS COREP60DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI SCHAFFER, JEAN E. · 1986 to 2012
$25.2M
DIABETES &RELATED METABOLIC DISEASEST32DK007120 · NIDDK · WASHINGTON UNIVERSITY · PI MARCO COLONNA, Maria Sara Remedi · 1986 to 2026
$15.7M
ADRENERGIC MECHANISMS IN METABOLIC PATHOPHYSIOLOGYR37DK027085 · NIDDK · WASHINGTON UNIVERSITY · PI CRYER, PHILIP E. · 2000 to 2009
$3.6M
NCATS NIH HHS UL1 TR000448NCRR NIH HHS M01 RR000036NCRR NIH HHS MO1 RR00036NCRR NIH HHS UL1 RR024992NCRR NIH HHS UL1 RR24992NIDDK NIH HHS P60 DK020579NIDDK NIH HHS P60 DK20579NIDDK NIH HHS R37 DK027085NIDDK NIH HHS R37 DK27085NIDDK NIH HHS T32 DK007120NIDDK NIH HHS T32 DK07120
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Blood GlucoseBrainDiabetes ComplicationsDiabetes MellitusDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic ComaFemaleHomeostasisHumansHypoglycemiaMaleRisk FactorsRisk Reduction BehaviorBlood Glucose

Identifiers

PMID19033403
PMCPMC2584119
OpenAlexW2014554878

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.