ArticleProceedings. Biological sciences2009
Lifetime reproductive success is maximized with optimal major histocompatibility complex diversity.
Article in Proceedings. Biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Forest Productivity Enhancement and Compensatory Growth: A Review and Synthesis.Frontiers in plant science · 2020Pooled it
- Evidence for genetically-based sperm discrimination in the vaginal tract of a primate species.PLoS biology · 2026Article
- Twenty years of tuberculosis-driven selection shaped the evolution of the meerkat major histocompatibility complex.Nature ecology & evolution · 2025Article
- Differences between mates at the TLR1Lb locus are associated with lower reproductive success in a long-lived seabird.Scientific reports · 2024Article
- A new method for ecologists to estimate heterozygote excess and deficit for multi-locus gene families.Ecology and evolution · 2024Article
- Organisation and evolution of the major histocompatibility complex class I genes in cetaceans.iScience · 2024Article
- Limited associations between MHC diversity and reproductive success in a bird species with biparental care.Ecology and evolution · 2024Article
- Response to MHC-based olfactory cues in a mate choice context in two species of darter (Percidae: Etheostoma).Ecology and evolution · 2024Article
- Evolutionary trade-offs constraining the MHC gene expansion: beyond simple TCR depletion model.Frontiers in immunology · 2023Article
- A Review of Suggested Mechanisms of MHC Odor Signaling.Biology · 2022Review
- High MHC diversity confers no advantage for phenotypic quality and reproductive performance in a wild bird.The Journal of animal ecology · 2022Article
- Feather chemicals contain information about the major histocompatibility complex in a highly scented seabird.Proceedings. Biological sciences · 2022Article
- Trans-specific polymorphism and the convergent evolution of supertypes in major histocompatibility complex class II genes in darters (Ecology and evolution · 2022Article
- Cross-continental experimental infections reveal distinct defence mechanisms in populations of the three-spined sticklebackProceedings. Biological sciences · 2021Article
- MHC class IIa haplotypes derived by high-throughput SNP screening in an isolated sheep population.G3 (Bethesda, Md.) · 2021Article
- Balancing selection, genetic drift, and human-mediated introgression interplay to shape MHC (functional) diversity in Mediterranean brown trout.Ecology and evolution · 2021Article
- Depletion of MHC supertype during domestication can compromise immunocompetence.Molecular ecology · 2021Article
- Article
- Long-term survey of sea turtles (Caretta caretta) reveals correlations between parasite infection, feeding ecology, reproductive success and population dynamics.Scientific reports · 2020Article
- Experimental Parasite Infection Causes Genome-Wide Changes in DNA Methylation.Molecular biology and evolution · 2020Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individual diversity at the major histocompatibility complex (MHC) is predicted to be optimal at intermediate rather than at maximal levels. We showed previously in sticklebacks that an intermediate MHC diversity is predominant in natural populations and provides maximal resistance in experimental multiple parasite infections in the laboratory. However, what counts ultimately is the lifetime reproductive success (LRS). Here, we measured LRS of six laboratory-bred sib-groups-to minimize the influence of non-MHC genes-three-spined sticklebacks (Gasterosteus aculeatus) during their entire breeding period, each in a seminatural enclosure in the lake of their parents, where they were exposed to the natural spectrum of parasites. We collected developing clutches at regular intervals and determined parenthood for a representative number of eggs (2279 in total) per clutch with 18 microsatellites. Both males and females with an intermediate MHC class IIB variant number had the highest LRS. The mechanistic link of MHC diversity and LRS differed between the sexes: in females, we found evidence for a trade-off between number of eggs and immunocompentence, whereas in males this correlation was concealed by different timing strategies of reproduction.
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