ArticleFungal genetics and biology : FG & B2009
Genome-wide analysis of Candida albicans gene expression patterns during infection of the mammalian kidney.
Article in Fungal genetics and biology : FG & B, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 100 citations in OpenAlex.
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- Stress- and metabolic responses of Candida albicans require Tor1 kinase N-terminal HEAT repeats.PLoS pathogens · 2022Article
- The effect of antifungal resistance development on the virulence of Candida species.FEMS yeast research · 2022Article
- The long non-coding RNA landscape of Candida yeast pathogens.Nature communications · 2021Article
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- Phosphate in Virulence ofJournal of fungi (Basel, Switzerland) · 2020Review
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- On Commensalism ofJournal of fungi (Basel, Switzerland) · 2020Review
- Biphasic zinc compartmentalisation in a human fungal pathogen.PLoS pathogens · 2018Article
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- The PHR Family: The Role of Extracellular Transglycosylases in Shaping Candida albicans Cells.Journal of fungi (Basel, Switzerland) · 2017Review
- Mitochondrial Complex V α Subunit Is Critical forFrontiers in microbiology · 2017Article
- Dual-species transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions.Scientific reports · 2016Article
- Pho4 mediates phosphate acquisition in Candida albicans and is vital for stress resistance and metal homeostasis.Molecular biology of the cell · 2016Article
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- In Vivo Transcriptional Profiling of Human Pathogenic Fungi during Infection: Reflecting the Real Life?PLoS pathogens · 2016Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Global analysis of the molecular responses of microbial pathogens to their mammalian hosts represents a major challenge. To date few microarray studies have been performed on Candida albicans cells derived from infected tissues. In this study we examined the C. albicans SC5314 transcriptome from renal infections in the rabbit. Genes involved in adhesion, stress adaptation and the assimilation of alternative carbon sources were up-regulated in these cells compared with control cells grown in RPMI 1640, whereas genes involved in morphogenesis, fermentation and translation were down-regulated. When we compared the congenic virulent C. albicans strains NGY152 and SC5314, there was minimal overlap between their transcriptomes during kidney infections. This suggests that much of the gene regulation observed during infections is not essential for virulence. Indeed, we observed a poor correlation between the transcriptome and phenome for those genes that were regulated during kidney infection and that have been virulence tested.
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