Trial reportPsychopharmacology2009
Modafinil improves rapid shifts of attention.
Trial report in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of stimulants for cognitive enhancement in non-attention deficit hyperactivity disorder youth: a systematic review.Addiction (Abingdon, England) · 2014Pooled it
- Moral decision making under modafinil: a randomized placebo-controlled double-blind crossover fMRI study.Psychopharmacology · 2019Trial
- Trial
- Early markers of cognitive enhancement: developing an implicit measure of cognitive performance.Psychopharmacology · 2013Trial
- Effects of modafinil on non-verbal cognition, task enjoyment and creative thinking in healthy volunteers.Neuropharmacology · 2013Trial
- Neuroenhancement: State of the Art and Future Perspectives.Clinical neuropsychiatry · 2021Article
- Cognitive Enhancement: Unanswered Questions About Human Psychology and Social Behavior.Science and engineering ethics · 2021Article
- Continuous performance test impairment in a 22q11.2 microdeletion mouse model: improvement by amphetamine.Translational psychiatry · 2018Article
- The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Modafinil enhances alerting-related brain activity in attention networks.Psychopharmacology · 2017Article
- A Novel Dopamine Transporter Inhibitor CE-123 Improves Cognitive Flexibility and Maintains Impulsivity in Healthy Male Rats.Frontiers in behavioral neuroscience · 2017Article
- Moral and social reasons to acknowledge the use of cognitive enhancers in competitive-selective contexts.BMC medical ethics · 2016Article
- Evaluation of the Effect of Modafinil on Cognitive Functions in Patients with Idiopathic Hypersomnia with P300.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Performance enhancement in the workplace: why and when healthy individuals should disclose their reliance on pharmaceutical cognitive enhancers.Frontiers in systems neuroscience · 2015Article
- The ethics of elective psychopharmacology.The international journal of neuropsychopharmacology · 2012Review
- Chronic smoking, but not acute nicotine administration, modulates neural correlates of working memory.Psychopharmacology · 2011Article
- Article
- [Neuro-enhancement. Brain doping].Der Nervenarzt · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe majority of studies investigating the cognitive effects of modafinil, a wake-promoting compound, demonstrate some improvements in attention. The potential of the drug to selectively benefit distinct components of attention has yet to be fully explored in healthy adults.
objectiveThe present study was conducted to investigate modafinil's effect on specific cognitive tasks that tax components of attention switching. One required the rapid switching of attention between stimuli, and another contained an embedded working memory component on top of the attentional shift requirements. Additionally, prospective memory was examined, which requires the interruption of an ongoing activity to retrieve and act upon a previously formed intention. MATERIALS AND
methodsHealthy non-smoking volunteers, matched on age, intelligence, and baseline cognitive ability, received either a capsule that contained 200 mg modafinil or placebo. Subjective measures of mood and physiological response were taken throughout the experimental session, and the tasks were completed between 2 and 3 h post-dosing.
resultsTwo hundred milligrams modafinil improved accuracy without a reaction time trade-off, in both conditions of the attention-shifting task, but only when resources were most challenged. In contrast, the drug afforded no improvement in prospective remembering or in the ongoing task that was interrupted.
conclusionModafinil appears to promote rapid switching of attention in conditions that are most demanding, whilst it offers no benefits in a task that requires unpredictable and infrequent disengagement of attention from an ongoing task in order to act upon an alternative task.
Indexed as
Identifiers
19031073What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.