Trial reportPsychopharmacology2009
Early effects of mirtazapine on emotional processing.
Trial report in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- A systematic review of the pharmacological modulation of autobiographical memory specificity.Frontiers in psychology · 2022Pooled it
- The effect of ketamine on affective modulation of the startle reflex and its resting-state brain correlates.Scientific reports · 2023Trial
- The effect of sertraline on emotional processing: secondary analyses of the PANDA randomised controlled trial.Psychological medicine · 2022Trial
- The effects of atorvastatin on emotional processing, reward learning, verbal memory and inflammation in healthy volunteers: An experimental medicine study.Journal of psychopharmacology (Oxford, England) · 2021Trial
- Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.Psychopharmacology · 2016Trial
- Selective serotonin reuptake inhibition modulates response inhibition in Parkinson's disease.Brain : a journal of neurology · 2014Trial
- A single dose of mirtazapine modulates neural responses to emotional faces in healthy people.Psychopharmacology · 2010Trial
- Negative bias in encoding and recall memory in depressed patients with inadequate response to antidepressant medication.Psychopharmacology · 2026Article
- Effects of ulotaront on brain circuits of reward, working memory, and emotion processing in healthy volunteers with high or low schizotypy.Schizophrenia (Heidelberg, Germany) · 2023Article
- Therapeutic Implications of microRNAs in Depressive Disorders: A Review.International journal of molecular sciences · 2022Review
- The Effect of the 5-HTFrontiers in psychiatry · 2022Article
- Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment.Psychopharmacology · 2021Review
- A single administration of the antibiotic, minocycline, reduces fear processing and improves implicit learning in healthy volunteers: analysis of the serum metabolome.Translational psychiatry · 2020Article
- Trait Sensitivity to Negative and Positive Feedback Does Not Interact With the Effects of Acute Antidepressant Treatment on Hedonic Status in Rats.Frontiers in behavioral neuroscience · 2020Article
- Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Interferon-α induces negative biases in emotional processing in patients with hepatitis C virus infection: a preliminary study.Psychological medicine · 2018Article
- Behavioral and emotional adverse events of drugs frequently used in the treatment of bipolar disorders: clinical and theoretical implications.International journal of bipolar disorders · 2016Article
- Effects of sertraline, duloxetine, vortioxetine, and idazoxan in the rat affective bias test.Psychopharmacology · 2016Article
- The effects of drugs on human models of emotional processing: an account of antidepressant drug treatment.Dialogues in clinical neuroscience · 2015Review
- Influence of Pharmacotherapy on Cognitive Functions in Depression: A Review of the Literature.Medical science monitor : international medical journal of experimental and clinical research · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAcute administration of selective serotonin and noradrenaline re-uptake blockers to healthy volunteers affects the processing of emotional information but it is not known if similar effects occur with antidepressants acting through other pharmacological mechanisms. Mirtazapine is a clinically established antidepressant with complex actions involving blockade of noradrenaline alpha(2)-adrenoceptors as well as a number of 5-HT receptor subtypes. The aim of the present study was to test whether, like monoamine re-uptake inhibitors, mirtazapine would also produce positive biases in emotional processing.
methodsWe studied 30 healthy volunteers who received either a single dose of mirtazapine (15 mg) or placebo in a parallel group, double-blind study. Two hours following medication administration, participants completed a battery of tasks testing various aspects of emotional processing including facial expression recognition, emotion potentiated startle, and emotional categorization and memory.
resultsCompared to placebo, mirtazapine significantly impaired the recognition of fearful facial expressions and reduced eye-blink responses in the emotion potentiated startle task. Participants receiving mirtazapine were also significantly quicker to respond to emotional self-relevant information in the categorization task and showed a positive bias in memory recall compared to those receiving placebo.
conclusionsOur findings indicate that mirtazapine reduces fear processing in healthy volunteers, an effect similar to that produced by repeated administration of selective serotonin re-uptake inhibitors. In addition, mirtazapine increased memory for likeable versus dislikeable self-relevant information suggesting an induction of positive bias in emotional memory. Such effects may be important for our understanding of the neuropsychological mechanisms of antidepressant action in both anxiety and depressive disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.