Trial reportEuropean journal of nutrition2009
The effect of marine n-3 fatty acids in different doses on plasma concentrations of Lp-PLA2 in healthy adults.
Trial report in European journal of nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase ALipids in health and disease · 2020Trial
- Trial
- Icosapent ethyl, a pure ethyl ester of eicosapentaenoic acid: effects on circulating markers of inflammation from the MARINE and ANCHOR studies.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2013Trial
- Omega-3 fatty acids and lipoprotein associated phospholipase A(2) in healthy older adult males and females.European journal of nutrition · 2011Trial
- Review
- Effects of Alpha-Lipoic Acid Supplementation on Cardiovascular Disease Risk Factors in β-Thalassemia Major Patients: A Clinical Trial Crossover Study.Journal of blood medicine · 2020Article
- The relationship between dietary patterns and lipoprotein-associated phospholipase A2 levels in adults with cardiovascular risk factors: Tehran Lipid and Glucose Study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2020Article
- The relation of diet with PAF and its metabolic enzymes in healthy volunteers.European journal of nutrition · 2015Article
- n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis.The British journal of nutrition · 2013Article
- The Mediterranean diet: effects on proteins that mediate fatty acid metabolism in the colon.Nutrition reviews · 2011Review
- Effects of dietary factors on lipoprotein-associated phospholipase A(2) (Lp-PLA (2)).Current atherosclerosis reports · 2011Review
- Antioxidant and inflammatory aspects of lipoprotein-associated phospholipase A₂ (Lp-PLA₂): a review.Lipids in health and disease · 2011Review
- Dietary, lifestyle, and clinical predictors of lipoprotein-associated phospholipase A2 activity in individuals without coronary artery disease.The American journal of clinical nutrition · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an emerging independent risk factor for cardiovascular disease (CVD). Lp-PLA(2) can be modified by lipid lowering drugs, but it is unknown whether diet can reduce plasma levels of Lp-PLA(2). AIM OF THE STUDY: The aim of the trial was to study the effect of marine n-3 polyunsaturated fatty acids (PUFA) on plasma Lp-PLA(2) levels in healthy subjects.
methodsSixty healthy subjects were randomized to a moderate dose (2 g) of n-3 PUFA, a high dose (6.6 g) of n-3 PUFA or olive oil (control) daily for 12 weeks. Plasma Lp-PLA(2) was measured at baseline and after the interventions.
resultsPlasma Lp-PLA(2) levels were unchanged in all three groups before and after the supplements. Neither did the results differ between groups. There was no correlation between the content of n-3 PUFA in platelets or granulocytes or plasma Lp-PLA(2).
conclusionMarine n-3 PUFA had no effect on plasma levels of Lp-PLA(2) in healthy adults and relatively young people.
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Registered trials
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