ArticleCognitive processing2009
Multimodal encoding in a simplified model of intracellular calcium signaling.
Article in Cognitive processing, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Embryos assist morphogenesis of others through calcium and ATP signaling mechanisms in collective teratogen resistance.Nature communications · 2024Article
- There's Plenty of Room Right Here: Biological Systems as Evolved, Overloaded, Multi-Scale Machines.Biomimetics (Basel, Switzerland) · 2023Article
- Spatial synaptic modulation through IP3 diffusion triggered by ECB: a computational study with an astrocyte-neurons model.Cognitive neurodynamics · 2021Article
- Improved tools to study astrocytes.Nature reviews. Neuroscience · 2020Review
- A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation.Computational and mathematical methods in medicine · 2020Article
- A Neuromorphic Digital Circuit for Neuronal Information Encoding Using Astrocytic Calcium Oscillations.Frontiers in neuroscience · 2019Article
- A Compartmental Model to Investigate Local and Global CaFrontiers in computational neuroscience · 2018Article
- Computational Models for Calcium-Mediated Astrocyte Functions.Frontiers in computational neuroscience · 2018Review
- Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study.Neural plasticity · 2016Article
- Systematic Characterization of Dynamic Parameters of Intracellular Calcium Signals.Frontiers in physiology · 2016Article
- Basis for a neuronal version of Grover's quantum algorithm.Frontiers in molecular neuroscience · 2014Article
- Ciliates learn to diagnose and correct classical error syndromes in mating strategies.Frontiers in microbiology · 2013Article
- Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity.Frontiers in computational neuroscience · 2012Article
- Self-repair in a bidirectionally coupled astrocyte-neuron (AN) system based on retrograde signaling.Frontiers in computational neuroscience · 2012Article
- A tale of two stories: astrocyte regulation of synaptic depression and facilitation.PLoS computational biology · 2011Article
- Article
- Nonlinear gap junctions enable long-distance propagation of pulsating calcium waves in astrocyte networks.PLoS computational biology · 2010Article
- The influence of the astrocyte field on neuronal dynamics and synchronization.Journal of biological physics · 2009Article
- Glutamate regulation of calcium and IP3 oscillating and pulsating dynamics in astrocytes.Journal of biological physics · 2009Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many cells use calcium signaling to carry information from the extracellular side of the plasma membrane to targets in their interior. Since virtually all cells employ a network of biochemical reactions for Ca(2+) signaling, much effort has been devoted to understand the functional role of Ca(2+) responses and to decipher how their complex dynamics is regulated by the biochemical network of Ca(2+)-related signal transduction pathways. Experimental observations show that Ca(2+) signals in response to external stimuli encode information via frequency modulation (FM) or alternatively via amplitude modulation (AM). Although minimal models can capture separately both types of dynamics, they fail to exhibit different and more advanced encoding modes. By arguments of bifurcation theory, we propose instead that under some biophysical conditions more complex modes of information encoding can also be manifested by minimal models. We consider the minimal model of Li and Rinzel and show that information encoding can occur by AM of Ca(2+) oscillations, by FM or by both modes (AFM). Our work is motivated by calcium signaling in astrocytes, the predominant type of cortical glial cells that is nowadays recognized to play a crucial role in the regulation of neuronal activity and information processing of the brain. We explain that our results can be crucial for a better understanding of synaptic information transfer. Furthermore, our results might also be important for better insight on other examples of physiological processes regulated by Ca(2+) signaling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.